Immunosuppresive Drugs

Question 1

Name 2 Cytotoxic drugs

Answer 1

1. Azatioprine

2. Mycophenolate Mofetil

Question 2

Azathioprine and Mycophenolate Mofetil are both _____ Drugs

Answer 2

Cytotoxic

Question 3

The cytotoxic drug, Mycophenolate Mofetil inhibits _____, which B and T-cells depend on for De Novo Purine synthesis since they can’t Salvage

Answer 3

IMP Dehydrogenase

Question 4

In regards to immunosuppresive drugs, To delay the use of Nephrotoxic Calcineurin inhibitors, _____ Therapy employs depleting agents and imune modulators.

Answer 4

Induction

Question 5

Sirolimus and Everolimus are both _____ Inhibitors

Answer 5

mTOR

Question 6

Name 3 Biologics (Antibodies) for Immunosuppresion

Answer 6

1. Antithymocyte Globulin
2. Muromonab-CD3
3. Daclizumab Antibody

Question 7

Name 2 Calcineurin inhibitors

Answer 7

1. Cyclosporine

2. Tacrolimus

Question 8

Cyclosporine and Tacrolimus are both _____ Inhibitors

Answer 8

Calcineurin

Question 9

Calcineurin dephosphorylates _____, which is a transcription factor that promotes IL-2 release

Answer 9

NFAT

Question 10

Antithymocyte Globulin, Muromonab-CD3, and Daclizumab are all known as ______ (_____)

Answer 10

Biologics (Antibodies)

Question 11

For Immunosuppressive Maintenance therapy, a typical combination includes a ______ inhibitor, ______, and a _____ Mofetil

Answer 11

Calcineurin, Glucocorticoids, Mycophenolate

Question 12

Name 2 mTOR inhibitors

Answer 12

1. Sirolimus

2. Everolimus

Question 13

The Cytotoxic Drug, Azathioprine, creates _____ which inhibits DNA synthesis and disrupts Hematopoeisis

Answer 13

6-Meracpto-P