Innate Immunity Flashcards
Dr. Langer
Paradoxically, Losing the complement inhibitory molecules “_____” or “_____”, you become more prone to infection because of C3 depletion
Factor H, Factor I
For an inflammatory response, the transcription factor ______ is particuarly important
NF-Kappa-Beta
In regards to complement, Factor I and Factor H both ______ _____
Inhibit Complement
The Alternative pathway has Spontaneous creation of _____
C3a
Type ____ and _____ IFNs are crucial to early antiviral defense
I, III
Plasmacytoid Dendritic cells are special because with TLR3,7,9 they can produce _____
Type I Interferons
What mechanism do neutrophils present antigen by?
They don’t!
In the alternative pathway _____ is a C3 convertase that cleaves C3 into C3b and C3a
C3bBb
The classical complement pathway begins through _____ _____ ____ ____
Antibody binding to Pathogen
Antiviral responses work through transcription factors of the _____ Response Factor Family
Interferon
The “____’s” of the complement tend to stick to cells
b
In the MBL and Classical complement pathway ______ is a C3 convertase that cleaves C3 into C3b and C3a
C4b2a
