8. Intro to Benign and Malignant Neoplasms Flashcards

1
Q

What is a neoplasm?

A

Uncontrolled cell proliferation leading to a mass or nodule

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2
Q

What is the difference between a neoplasm and a tumour?

A

Neoplasm is a lump from uncontrolled cell proliferation

Tumour is a lump due to any cause

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3
Q

What is a hamartoma?

A

An excess of tissue that is normal to the site

Haphazardly arranged but benign

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4
Q

What does a benign neoplasm look like macroscopically?

A

Round, smooth, homogenous surface

Encapsulated or surrounded by fibrous tissue

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5
Q

What is a benign neoplasm in squamous epithelium called?

A

Papilloma

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6
Q

What is a benign neoplasm in glandular epithelium called?

A

Adenoma

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7
Q

What is a benign neoplasm in transitional epithelium called?

A

Transitional papilloma

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8
Q

Where is a papilloma found?

A

Skin

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9
Q

Where is an adenoma found?

A

GIT, thyroid, ovary, breast

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10
Q

Where is a transitional papilloma found?

A

Bladder

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11
Q

What is a benign neoplasm of cartilage called?

A

Chondroma

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12
Q

What is a benign neoplasm of smooth muscle called?

A

Leiomyoma

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13
Q

What are the effects of a benign tumour?

A

Lump
Bleeding
Obstruction
Pain

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14
Q

Why is there no such thing as a benign lymphoid neoplasm?

A

By definition has access to lymph, giving it the ability to metastasise and is therefore always malignant

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15
Q

What is a borderline neoplasm?

A

Have some nuclear features that suggest malignancy but not enough to be certain of malignancy

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16
Q

How can you differentiate between a benign and malignant neoplasm?

A

Altered morphology
Architectural features
Altered function and genetic profile
Malignant often cause haemorrhage, necrosis and invasion

17
Q

How is the cell different in a malignant neoplasm?

A

Pleomorphism (change in size and shape)
Hyperchromasia
High mitotic activity
Increase nucleus/cytoplasm ratio

18
Q

How is the architecture different in a malignant neoplasm?

A

More haphazard layout of cells

Cells at surface are more immature

19
Q

What is a metastasis?

A

Malignant neoplasm that has spread from the primary site to a different site

20
Q

What is metaplasia?

A

Transformation of one mature epithelial type into another in response to a stimulus