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FIP > 21. Malignant Lymphoid Proliferations > Flashcards

21. Malignant Lymphoid Proliferations Flashcards

1
Q

What is a haematological malignancy?

A

A cancer of any blood cell

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2
Q

How can lymphomas be classified?

A

Hodgkin’s vs non-hodgkin’s

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3
Q

How can leukaemias be classified?

A

Acute vs chronic

Myeloid vs lymphoid

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4
Q

Which cloned cell is responsible for 90% of lymphomas?

A

B cells

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5
Q

What are the manifestations of lymphomas

A 
Painless lymphadenopathy
Shortness of breath, pleural effusion
Abdominal distension, ascites
Fatigue
B symptoms
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6
Q

What are B symptoms?

A

Fever
Night sweats
Weight loss

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7
Q

What is Ann Arbor Staging?

A

Used to stage lymphomas

  1. single lymph node
  2. one side of diaphragm
  3. both sides
  4. disseminated
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8
Q

Further classify non-Hodgkins lymphoma

A

B and T cell

Higher grade diseases have less mature cells

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9
Q

Further classify Hodgkins lymphoma

A

Classical

Non-classical

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10
Q

What does CD stand for?

A

Classification Determinant

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11
Q

What type of cell can be present in Hodgkins lymphoma?

A

Reed Sternberg cells

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12
Q

What markers are present from reed sternberg cells?

A

CD30 and CD15

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13
Q

What age group has the highest peak of Hodgkin’s lymphoma?

A

20s-30s

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14
Q

What lymph nodes are often enlarged in Hodgkin’s lymphoma?

A

Cervical

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15
Q

What symptoms are specific to Hodgkin’s lymphoma?

A

Pain after alcohol

Pruritis

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16
Q

How are lymphomas staged?

A

PET-CT
Bone aspirate or trephine
B symptoms
LDH level

17
Q

Name 3 high grade B cell lymphomas

A

Burkitt’s
Diffuse Large B-Cell Lymphoma
Mantle cell lymphoma

18
Q

What virus and translocation are associated with Burkitt’s lymphoma?

A

EBV
c-MYC translocation
t(8;14)

19
Q

Name a low grade T cell lymphoma

A

Mycosis Fungoides

20
Q

Name a high grade T cell lymphoma

A

EATL

21
Q

What disease is EATL associated with?

A

Coeliac disease

FIP (36 decks)

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