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FIP > Revision Questions > Flashcards

Revision Questions Flashcards

1
Q

Name of cell present in Hodgkin’s lymphoma

A

Reed Sternberg

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2
Q

What CD markers are present on Reed Sternberg cells?

A

CD30

CD15

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3
Q

What translocation is present in Burkitt’s lymphoma?

A

8;14

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4
Q

What type of lymphoma is cyclin D1 positive?

A

Mantle cell

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5
Q

What are the CD markers in mantle cell lymphoma?

A

CD20

CD79

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6
Q

What translocation is present in mantle cell lymphoma?

A

11;14

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7
Q

Where does mycosis fungoides lymphoma present?

A

Skin

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8
Q

What markers are present in small cell lymphocytic lymphoma?

A

CD5

CD23

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9
Q

What gene is over expressed in follicular lymphoma?

A

BCL2

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10
Q

What CD marker is present in follicular lymphoma?

A

CD10

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11
Q

What neoplasms cause enlargement of the thymus?

A

Thymomas
Lymphomas
Germ cell tumours
Carcinoid tumours

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12
Q

What diseases are thymomas associated with?

A

Myasthenia gravis
RH
Sjogrens

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13
Q

What is the pathogenesis of myeloproliferative cell neoplasms/disorders?

A

Mutation in a gene coding for a tyrosine kinase: JAK2

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14
Q

Classify myeloproliferative disorders

A

CML
Myelofibrosis
Polycythemia rubra vera
Thrombocytosis

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15
Q

What investigations should be done into myeloproliferative disorders?

A 
FBC
Leukocyte ALK phos
Bcr-abl gene arrangement
Uric acid
JAK2
BMT
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16
Q

What is myelodysplastic syndrome?

A

Neoplastic proliferation of stem cells in bone marrow

Pre-leukaemic disorder

17
Q

What is the usual clinical clue of myelodysplastic syndrome?

A

Low peripheral cell count with hypercellular marrow

18
Q

How can CML be differentiated from an acute infection?

A

CML granulocytes are LAP negative
Mostly basophils
t(9;22)

19
Q

What nuclear stain is present in lymphoblasts?

A

Tdt

20
Q

How are myeloblasts differentiated from other cells?

A

Have auer rods

21
Q

What is Lynch syndrome?

A

Abnormality of DNA mismatch repair genes

Colorectal and endometrial carcinoma

FIP (36 decks)

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