ABX in pregnancy

Question 1

ABX safe in pregnancy

Answer 1

Penicillins
Cephalosporins
Erythromycin, Azithromycin
Nitro (avoid at term)
Metronidazole (caution in 1st trimester)
Fosfomycin

Question 2

Abx to try and avoid (CAUTION) in pregnancy

Answer 2

Trimethoprim- Neural tube defects (avoid 1st trimester)

Chloramphenicol- Grey Baby syndrome

Clindamycin - Only use if indicated

Vancomycin- Blood dyscarias etc

Gent- Ototoxic and nephrotoxic

Question 3

ABX TO COMPLETELY AVOID

Answer 3

Tetracylines- Tooth discolouration, bone growth

Quinolones- Risk of fatal cartilage damage

Sulfonamides- Folate antagonism

Rifampicin - haemorrhage

Fluconazole - Teratogenic at high doses