Extra Flashcards
(20 cards)
Vancomycin dose for first episode of severe/non severe CDIFF
125mg QDS for 10 DAYS
How long is the initial phase of TB treatment
2 months
How long is the maintenance phase of TB treatment
4 months
Notable side effects of trimethoprim
SJS
Blood disorders
Cautions of trimethoprim
G6PD deficiency
Elderly
Blood disorders
Asthma
Monitoring requirements of metronidazole are required after 10 days treatment what is monitored
LFT
FBC
Clindamycin has good…
Anaerobic coverage
Indications of clindamycin
Staph going and bone infections
Intra abdominal sepsis
Side effects of clindamycin
Oesphagael disorders
Blood disorders
Jaundice
SJS
Monitoring in infants is required for clindamycin if using for 10+ days what is required to be monitored?
Hepatic and renal function
What can rapid infusion of amphotericin B cause
Risk of arrythimias
MHRA Amphotericin B
Serious harm + fatal OD have occurred following confusion between liposmal, pegylated liposomal and lipid complex formulations
When can carbapenems not be used
Epilepsy (REDUCES SV efficacy)
Carbapenems/cephalosporins x warfarin
Increases warfarin’s anticoagulant effect by killing the normal flora that synthesis vitamin K
Cephalosporins x aminoglycosides
Cephalosporins may increase the nephrotoxicity of aminoglycosides
Tazocin and sodium
Each dose contains 11mmol of sodium even before infusing into fluid (which would have more sodium) - care is required especially in HF patients
Fluconazole systemic side effects
GI UPSET
Hepatitis
Hypersensitivity
More severe side effects of fluconazole
Severe hepatic toxicity
Prolonged QT
Anaphylaxis
CI/cautions of fluconazole
- Caution in hepatic disease
- Dose reduction in moderate renal impairment
- AVOID IN PREG- RISK of malformations
Risks factors for oral thrush
Using antimuscarinics- decreased slavia
ABX use
Elderly
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