Acute Inflammation Flashcards Preview

CMBM exam 4 > Acute Inflammation > Flashcards

Flashcards in Acute Inflammation Deck (40):
1

What are the three purposes of inflammation?

To contain, neutralize and remove

2

What are the two main lines of defense?

Natural epithelial barriers
Inflammation

3

What are the natural epithelial barriers?

Keratinization
Acidic surfaces
Mucinous surfaces

4

What are the non-specific cells which cause inflammation

Mast cells, dendritic cells and macrophages

5

What does it mean when there is a "triple response of lewis"?

Mast cells releasing histamine
Red line, flare, wheal

6

Which immunoglobulin binds to mast cells?

IgE

7

What is the specific immunity types in regards to inflammation?

Humeral and cellular immunity

8

What is the colloquial term for urticaria?

Hives

9

What can be seen in the cells of someone who has urticaria?

Marked edema

10

If pus develops in an area (like a toe) with red streaks, the skin is sloughing off and ulceration what bacteria could cause this?

Strep

11

What is calor and what causes it?

Heat from vasodilatation

12

What is rubor and what causes it?

Redness from vasodilatation

13

What is tumor and what causes it?

Swelling from vascular permeability

14

What is dolor and what causes it?

Pain from mediator release/PMNs

15

What is functio laesa and what causes it?

Loss of function because you lost function

16

What are the major components of acute inflammation?

Vascular changes
Cellular events
Chemical mediators of inflammation

17

What is transient vasoconstriction?

The first action that happens after an injury which only lasts a few seconds

18

Following vasoconstriction what happens in an injury?

Vasodilation of precapillary arterioles to inc blood flow

19

Blood stasis occurs after vasodilation. Then the permeability of the venules _____.

Increase

20

Looking at a new injury what pattern of visual cues would you see?

Pale to red to edema

21

What is edema?

Increase in fluid
Look for pitting vs no pitting

22

What is exudation?

And increase in cell number
Look for the amount of cells or if there is pus

23

In vascular permeability how does the protein exit a vessel?

By the decrease of intravascular osmotic pressure or the increase of intravascular hydrostatic pressure

24

When would endothelial gaps be seen in cell junctions?

Immediate transient response
Histamine, bradykinin, leukotrienes, substance P

25

What causes a prolonged leakage of inflammatory products?

Vasculitis
ex. sunburn, x-rays, toxins

26

What is transcytosis?

Various macromolecules are transported across the interior of a cell via vesicles

27

What is angiogenesis?

Repair
Process through which new blood vessels form from pre-existing vessels

28

What are the characteristics of transudate?

Normal vascular permeability
Plasma ultrafiltrate
Low protein
Specific gravity < 1.02

29

What are the characteristics of exudate?

Increased vascular permeability
High protein and cell debris
Specific gravity > 1.02

30

What would you call exudate in the lungs?

Pneumonia

31

If a pt has pain over the right lower quadrant with rebound tenderness, what could it be?

Acute Appendicitis

32

What mediators regulate pain?

Prostaglandin and bradykinin

33

What chemical mediators participate in phagocytosis?

Complement C3b and IgG

34

Which chemical mediators will show erythemia?

Histamine and serotonin

35

What chemical mediators will cause the experience of a fever?

Interleukin-1 and necrosis factors (tissue destruction)

36

When leukocytic infiltrate is observed, what mediators would have appeared?

Leukotriene and HPETE

37

After a prolonged period of time after an injury and suturing you may see a nodule at the incision site. Which cell would appear for this type of inflammatory response?

Giant cells

38

What inflammatory cells participant in clearance?

Hydrogen peroxide

39

What types of injury could cause a pulmonary thromboembolism?

Swollen leg below the knee, pain with motion, tenderness and strong aterial pulses

40

If a pt appears with a bacterial infection (acid fast) which cells are most likely to appear?

Macrophages