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Flashcards in Additional Immunology Deck (18):
1

What are some different classes of helper T cells?

TH1

TH2

TH17

TFH

 

2

What is the defining cytokine of TH1?

IFN-gamma

3

What are the defining cytokines of TH2?

IL-4

IL-5

IL-13

4

What are the defining cytokines of TH17?

IL-17

IL-22

5

What are the defining cytokines of TFH?

IL-21

IFN-gamma or IL-4

6

What is the principle target of TH1?

Macrophages

7

What is the principle target of TH2?

Eosinophils

8

What is the principle target of TH17?

Neutrophils

9

What is the principle target of TFH?

B cells

10

What has CD4 protein on its surface and what does this do?

Helper T cells which binds to MHCII

11

Which of the different classes of helper T cells are intra and extracellular?

TH1 is intracellular, the rest are extracellular

12

What kind of antigens are presented on MHCI receptor compared to MHCII?

MHCI is from inside the cell, binds to cytotoxic which destoys the cell

MHCII is from outside the cell and binds to helper cells

13

What is the process of helper T cell activation?

1) MHCII antigen presnting binds to TCR on helper T cell

2) Helper T cell divides forming effector and memory cells

3) Releases cytokines which bind to other activated cells and help them fight the pathogen

4) Helper T cell binds to MHCII on B cell which is presenting the antigen

5) B cell divides and produces antibodies

14

What does CD8 do?

Found on cytotoxic T cells and binds to MHCI receptor on infected cells which are then killed

15

What is the process of cytotoxic T cell activation?

1) TCR on T cell binds to MHCI of an infected cell

2) T cell divides and produces effector T cells and memory cells

3) Cytotoxic T cell binds to an infected cell, releasing perforin which forms pores in the target cell

4) Releases granzyme that enters the target cell and induces apoptosis

16

What are the 2 receptor on natural killer cells?

Inhibitory receptor

Activation receptor

17

What does the inhibitory receptor bind to?

MHC1 on healthy cells that present self antigens

18

When does the natural killer cell kill?

When it does not bind to MHCI presenting self antigens