Adenoviruses Flashcards Preview

Microbiology Exam #1 > Adenoviruses > Flashcards

Flashcards in Adenoviruses Deck (31):
1

Adenoviruses have what kind of DNA?

Linear, Double-stranded

2

What type of caspid does it have?

Icosahedral

3

Does the virus have an envelope?

No

4

What are the fibers with antigen specificity called?

Hemagglutinin

5

Adeno is the only virus with....

A fiber in every vertices

6

Most of the body of the adenovirus is comprised of...

Hexon

7

How does adeno bind?

Attachment to the Coxsackie/Adenovirus Receptor
Interactions between the base and av integrins lead to internalization.

8

Where does transcription/replication occur?

Nucleus of Infected Cell

9

What divides early and late DNA replication?

Viral DNA replication

10

What are immediate early genes? Name two in adeno.

Protein products needed for DNA synthesism altered host cell genes, and late gene transcription.

E1A and E1B

11

How does adeno present?

Respiratory tract diseases -- ARS
Ocular Diseases -- Pharyngoconjunctival fever, epidemic keratoconjunctivitis
Acute Hemorrhagic Cystitis
Gastroenteritis
Inf. in immunocompromised

12

Acute respiratory disease is caused by which adenos?

Types 1, 2, 5, and 6

13

Symptoms of Acute Respiratory Disease?

Fever, Runny Nose, Cough, Sore Throat for 3-5 days
50% of cases -- prolonged fever, leukocytosis
Bronchitis, Pneumonia, Conjunctivitis

14

Fatal pneumonia is associated with what serotypes?

3, 7, 14, 21, 30

15

What serotype is "Super Cold"

14

16

What is pharyngoconjunctival fever?

Fever, Sore Throat, Corysa, red eyes.
May or may not have respiratory symptoms. Mya be one or both eyes.

17

Which Adeno strains make pharyngoconjunctival fever?

3, 4, and 7

18

What is epidemic keratoconjunctivitis?

highly contagious, bilateral palpebral, follicular conjunctivitis with keratitis. Inflammation can last for weeks, scarring and visual impairment may follow.

19

What adeno serotypes are associated with epidemic keratoconjunctivitis?

8, 19, 37

20

What is acute hemorrhagic cystitis?

Increased frequency, pain, and bloody urine

21

What serotypes are associated with acute hemorrhagic cystitis?

11 and 21

22

Symptoms of gastroenteritis

Common cause of infantile diarrhea in the daycare center
Fever

23

Which adeno serotypes are associated with enteritis?

40 and 42

24

What might cause a patient to be immunocompromised?

SC Transplant, T cell depletion, high dose Ab therapy, immunosuppresion

25

How might adeno present in an immunocompromised patient?

Hemorrhagic cysts, pneumonitis, hepatitis, gastroent., nephritis

26

Who is adeno transmitted?

Droplet inhalation, fecal-oral route

27

Types of infections caused by adeno?

Lytic infection, Latent infection

28

Relationship between Adeno and cancer?

Viral DNA integration can cause oncogenic transformation

29

What groups are most at risk for adeno?

Children Under 14
People in Crowded Areas

30

What group commonly suffers adeno outbreaks?

Military recruits

31

How is Adeno controlled?

Prevention by vaccine