VZV, EBV, CMV, Herpes 4-8

Question 1

Common name for varicella?

Answer 1

Chicken Pox

Question 2

CP is result of ______ infection of VZV

Answer 2

Primary

Question 3

Symptoms of Varicella

Answer 3

Vesicles, Pustule, Crust, Scabbed Lesions
Spreads of entire body, but mostly trunk
Presence on scalp is unique

Question 4

Potential side effect of adult chicken pox?

Answer 4

Interstitial pneumonia

Question 5

Common name for herpes zoster?

Answer 5

Shingles

Question 6

Where does shingles come from?

Answer 6

Latent varicella infection

Question 7

Clinical presentation of shingles?

Answer 7

Painful, Unilateral vesicular rash

Blisters follow dermatomes

Question 8

VSV pathogenesis?

Answer 8

Inf. respiratory tract
reticuloendothelial system
viremia
Latent in DRG/CN Ganglia

Question 9

Epstein Barr genome?

Answer 9

dsDNA

icosahedral capsid

Question 10

How does EBV replicate?

Answer 10

Attach of Bcells and nasopharyngeal epithelium

Internalize via cytoplasmic vesicles

Question 11

Three potential EBV infection outcomes?

Answer 11

Replication in B cells
Latent B cell infection (esp. with T cells around)
Stimulate and immortalize B cells

Question 12

Non-permissive B cell infection genes produced?

Answer 12

Epstein Barr Antigens
Latent Membrane Proteins
Latent Proteins

Question 13

What do EBNAs and LPs do?

Answer 13

DNA binding proteins for establishing infection

Question 14

What do LMPs do?

Answer 14

Membrane proteins with oncogene like activity

Question 15

What genes are expressed in latent memory B cells?

Answer 15

EBNA and LMP

Question 16

Infection associated with Permissive epit. and B cell EBV?

Answer 16

heterophile Antibody Positive Infectious Mononucleosis

Question 17

Symptoms of eterophile Antibody Positive Infectious Mononucleosis

Answer 17

Lymphodenopathy, Splenomegaly, Exudative pharyngitis

Question 18

What is HBV-Induced Lymphoproliferative Disease?

Answer 18

Lymphocytes produced in excessive quantities
Lack of T cell Immunity
Occurs in BM, Kidney, Liver, Heart, Lung transplant

Question 19

What is Burkitt’s lymphoma?

Answer 19

Agressive B cell Lymphoma of the jaw/face
Poorly differentiated B cells
Usually children
Associated with HIV

Question 20

Describe nasopharyngeal carcinoma.

Answer 20

Cancer of nasopharynx
Endemic in Asia/N Africa
Adults
Epithelial Cells
Nasal Discharge/Bleeding, Ear Infections, Metastasis

Question 21

Pathogenesis of EBV

Answer 21

Transmitted by saliva
Acute – Vermia and infection of lymphoreticular
Latent – Presents in B cell and epithelial cells

Question 22

What is a Downey Cell?

Answer 22

Atypical T-cell

Abundant pale cytoplasm, basophilic cytoplasm, insinuation btw RBCs

Question 23

In adults, how can you detect EBV infection?

Answer 23

Heterophile Antibody

Question 24

Important knowledge for EBV recovery?

Answer 24

Avoid Spleen Trauma

Question 25

CMV full name?

Answer 25

betaherpesvirinae

Question 26

Types of CMV infection?

Answer 26

Congenital Infection | Heterophile-negative mononucleosis

Question 27

Clinical Presentation of Congenital CMV?

Answer 27

Primary inf. of pregnant mother spread via placenta | Most babies born have no CMV symptoms

Question 28

Possible CMV symptoms

Answer 28

Liver+spleen+lung ploblems, Seizures hearing/Vision Loss, Mental Disability Seizures, Death

Question 29

Heterophile-negative mononucleosis test result?

Answer 29

Negative Paul-Bunell Test

Question 30

CMV symptoms in AIDS patients?

Answer 30

Pneumonia, Gastroenteritis, Retinitis, Encephalitis

Question 31

Pathogenesis of CMV?

Answer 31

Replic. in Salivary Glands and Kidneys Produces Cowdry Type A cells Persistent salivary infection, breasts, kidneys

Question 32

CMV classic sign

Answer 32

Owl's Eye seen in lung section

Question 33

How to get rid of CMV?

Answer 33

You don't.

Question 34

Drugs used against CMV?

Answer 34

Gancyclovir Valganciclovir Foscarnet Cidofovir

Question 35

Herpes 6 and 7 infects what cell types?

Answer 35

Lymphocytes, Monocytes, Epithelial, and endothelial cells

Question 36

Where does Herpes 6 and 7 replicate?

Answer 36

Salivary glands

Question 37

Common infection caused by Herpes 6 and 7?

Answer 37

Roseola

Question 38

What is Roseola?

Answer 38

Common, Mild, Febrile disease of infant

Question 39

Clinical presentation of Herpes 6 and 7 in adults?

Answer 39

Encephalitis, Lymphodenopahthy, Hepatitis

Question 40

Herpes Virus 8 is associated with....

Answer 40

Kaposi's sarcoma

Question 41

Primary target of Herpes Virus 8?

Answer 41

B cells

Question 42

What is Kaposi's Sarcoma?

Answer 42

Spindle cell tumor, endothelial lineage Patches of abnormal tissue grown under skin/in mucosa Red/Purple Color Can spread to GI or lungs -- Bleeding

Question 43

Herpes Virus 8 is especially prevalent in what population?

Answer 43

Gay/Bisexual Men and Africans