Herpes Virus - HSV 1 and HSV 2

Question 1

Genome?

Answer 1

dsDNA

Question 2

Reservoir?

Answer 2

Humans

Question 3

Where does the envelope come from?

Answer 3

Nucleus

Question 4

Alpha-Herpes includes what viruses?

Answer 4

Herpes Simplex 1 and 2

Question 5

HSV encodes what enzymes?

Answer 5

DNA-dependent DNA pol

Thymidine Kinase

Question 6

Clinical presentation of HSV?

Answer 6

Usually asymptomatic

Both can cause oral and genital infections

Question 7

Two types of oral herpes?

Answer 7

Acute Herpetic gingivostomatitis

Cold Sores/Herpes Labialis

Question 8

Symptoms of Acute Herpetic gingivostomatitis

Answer 8

Clear lesions, then white-ish ulcers
Covers mouth, pharynx
Discomfort, fever, gingivitis, lymphendectomy, difficulty speaking/eating

Question 9

What age group usually gets Acute Herpetic gingivostomatitis?

Answer 9

Kids 1-4

Question 10

What herpes usually causes oral herpes?

Answer 10

HSV-1

Question 11

Describe cold sores.

Answer 11

Vesicles, Ulceration, Inflammation, Edema

Question 12

What is herpes keratitis? Which virus usually?

Answer 12

Herpes of the eye, HSV-1

Question 13

Clinical presentation of herpes keratitis?

Answer 13

Unilateral Red Eye, Pain, Photophobia
Dendritic Corneal Ulcer
Most frequent cause of blindness.

Question 14

What is herpes whitlow?

Answer 14

Herpes of small wounds of hands/wrist through secretions

Question 15

Clinical presentation of herpes whitlow?

Answer 15

Pain and Burning, Erythema, Edema, Vesicles, Fever

Question 16

What is herpes gladitorum?

Answer 16

Clusters of blisters seen on head/neck that are common among contact sports

Question 17

What is eczema herpeticum?

Answer 17

Rare, pediatric infection at sites of skin damage by eczema/dermatitis

Question 18

Typical virus to cause genital herpes?

Answer 18

HSV-2

Question 19

Symptoms of genital herpes?

Answer 19

Small red bumps, blisters, open sores
Pain/Itching
Flu-like symptoms

Question 20

Typical virus to cause HSV encephalitis?

Answer 20

HSV-1

Question 21

HSV encephalitis claim to fame?

Answer 21

Most common viral encephalitis

Question 22

Clinical presentation of HSV encephalitis?

Answer 22

Early - Fever, headache, Nausea

Late - Encephalopathy (lethargy, confusion, delirium)

Question 23

What part of the brain is typically targeted?

Answer 23

Temporal Lobes

Question 24

What is seen in CSF on HSV encephalitis

Answer 24

Elevated Proteins, WBC
Low Glucose
RBC from hemorhage

Question 25

Most common viral cause of HSV meningitis?

Answer 25

HSV-2

Question 26

HSV Meningitis is often a complication of...

Answer 26

genital herpes

Question 27

Most common viral source of neonatal herpes?

Answer 27

HSV-2

Question 28

How is neonatal herpes transferred?

Answer 28

During delivery through infected maternal genital tract Transplacental Hospital Acquired

Question 29

Post-birth neonatal herpes symptoms?

Answer 29

Usually on skin, eyes, mouth | Encephalitis is common

Question 30

Pre-birth neonatal herpes symptoms?

Answer 30

Premature birth, low birth-weight | Microcephaly, hydrocephalus, chorioretinitis

Question 31

Easy way to guess which HSV it is?

Answer 31

``` HSV-1 = above the waist HSV-2 = Below the waist ```

Question 32

Pathogenesis?

Answer 32

Establishes latent infection in sensory ganglia | Upon reactivation, spreads out from ganglion to make lesions

Question 33

What is cowdry type A?

Answer 33

Intranuclear eosinophilic amorphous | droplet like bodies surrounded by clear halo

Question 34

Virus is transmitted through...

Answer 34

Saliva, vaginal secretions, lesion fluids

Question 35

Control of Herpes?

Answer 35

Cyclovirs Arabinoside Iododeoxyuridine Trifluridine