Parvoviridae -- Human Parvovirus (B19) Flashcards Preview

Microbiology Exam #1 > Parvoviridae -- Human Parvovirus (B19) > Flashcards

Flashcards in Parvoviridae -- Human Parvovirus (B19) Deck (21):
1

Parvovirus claim to fame?

Smallest virus.

2

Genetic informaiton

ssDNA
Icosahedral
Non-enveloped

3

How many serotypes?

One

4

Most common symptom?

Rash in children

5

Cells targeted?

Mitotically active, especially erythroid lineage cells of bone marrow

6

Name of Erythrocyte P antigen

Globoside

7

How does ssDNA become ds in the host?

Host DNA polymerases found in growing cells

8

Transcriptions/Replication/Assembly occur in....

Nucleus

9

Virus released by...

Cell lysis

10

How does Parvo present?

Early -- Sore throat, fever, upset stomach, headache
Late -- Rash

11

Bonus adult complications?

Joint involvement/soreness

12

How is the rash in Parvovirus often described?

Slapped Cheek

13

Parvovirus infection in pregnancy associated with...

Increased Fetal Loss

14

What is fetal hydrops?

Edema of the fetus - symptoms include...
Anaemic heart failure
Pleural Effusion
Hepatosplenomegaly
Ascites

15

How is fetal hydrops often diagnosed?

Ultrasound

16

Why is Parvovirus especially dangerous for anemic people?

Can cause a cessation of RBC production
Causes Aplastic Crisis

17

Symptoms of Aplastic Crisis?

Tiredness
Pale skin, lips, nails
Shortness of breath, headached, fever, fainting

18

How is Parvovirus transmitted?

Aerosol, Transplacental

19

Who typically gets parvovirus?

School-age and daycare kids

20

Treatment?

None

21

Prevention?

None