Togaviridae -- Rubella Flashcards Preview

Microbiology Exam #1 > Togaviridae -- Rubella > Flashcards

Flashcards in Togaviridae -- Rubella Deck (14):
1

Describe the genetic set up.

+ssRNA genome
Icosahedral caspid
Enveloped

2

Inactivators of rubella include...

Chemical Agents, UV, pH, Heat

3

How does replication happen?

+RNA immediately binds to ribosomes as mRNA
2/3 genome is made a polypeptide (later cleaved into 4 protein protease and polymerase)
1/3 genome gives caspid and envelope proteins

4

Other name for rubella?

German measles

5

Why give a shit about rubella?

Congenital Rubella Syndrome

6

How is it transmitted?

aerosol

7

Characteristic symptom?

Swollen lymph glands behind ears/in neck
Rash that starts on face/neck, and moves down the body

8

Bonus symptom sometimes seen in adults?

Arthritis

9

Does rubella typically pass from mother to child?

In 90% of cases that the mother is infected

10

Why care if the mother passes German Measles?

Miscarriage, Stillbirth or severe birth defects (Congenital Rubella Syndrome)

11

Symptoms of Congenital Rubella Syndrome

Impaired Hearing (85%)
Heart Defects (50%)
Eye Defects (43%)
Autism, Thyroid Dysfunction

12

Pathogenesis of Rubella?

Inf. nasopharynx/lungs
Spreads to Lymph Nodes and monocyte system
Viremia --> to other tissues/skin
In immunologically deficient pregnant woman, infects placenta/fetus

13

Diagnosis of Rubella?

Rubella IgM + Rash

14

Prevention of Rubella?

MMR