Hepatitis Viruses Flashcards Preview

Microbiology Exam #1 > Hepatitis Viruses > Flashcards

Flashcards in Hepatitis Viruses Deck (45):
1

Hepatitis A is what type of virus?

Picorna

2

Hepatitis B is what type of virus

Hepadna

3

Hepatitis C is what type of virus>

Flavivirdae

4

Hep A Public health claim to fame?

Most common vaccine-preventable disease in the world

5

Hep A genome?

+ssRNA with 5'viral protein
Icosahedral capsid
No Envelope

6

Hep A inactivated by...

Chlorine treatment
Formalin
Peracetic Acidbeta-propiolactone
UV radiation

7

Describe acute hepatitis infection.

Flulike Symptoms
Icteric Phase --> Dark urine, pale stool, jaundice, ab pain
Usually complete recovery

8

What is icterus?

Jaundice

9

Cause of jaundice?

Increased bilirubin levels
RBC death, heme converted to bilirubin
Bili. conjugated in liver, enters bile, and excreted

10

Long term consequences of Hep A?

No chronic state, No cancer

11

Serological course of Hep A

ALT spike, IgM anti HAV, Other anti-HAV

12

How does Hep A transfer?

Close personal contact
contaminated food/water
Blood Exposure

13

How is Hep A diagnosed?

ELISA identification of HAV-IgM Abs

14

Ig levels of acute infection?

IgG and IgM

15

Ig levels of very early acute?

IgM

16

Ig levels of person with no acute HAV infection?

IgG

17

Ig levels, no infection or immunity

None

18

Hep B genome?

Circular ds DNA
icosahedral
envelope

19

Proteins in Caspid?

Hep B Core Antigen
Soluble Core Protein

20

Clinical Presentation of Acute Hep B

Most Asymptomatic
Jaundice hepatitis
Fulminant hepatits - GI bleeding, coming, encephalopathy, ascites

21

Clinical Presentation of Chronic Hep B

Can be asymptomatic
Similar symptoms
May lead to serious liver damage, failure, cirrhosis, cancer

22

Pathogenesis of Hep B

HBV infects liver
Immune mediated lysis of infected cells produce symptoms to resolve infection
Insufficient immunity leads to chronic disease

23

Acute Hep B serological course?

HBsAg (IgG), then IgM anti-HBc, then anti-HBs

24

Chronic Hep B serological course?

HBsAg, then IgM anti-HBc

25

How is Hep B transmitted?

Blod, Sex, Direct Contact, Transplacental

26

Treatment for Hep B?

Reverse Transcriptase Inhibitor (Lamivudine, Adefovir)

27

Control of Hep B?

Scanning donated blood, Vaccination

28

Infection with Hep C causes... (3)

Chronic Hepatitis
Cirrhosis
Hepatocellular Carcinoma

29

Hep C genome?

+ssRNA
Enveloped

30

Hep C Clinical Presentation?

Usually Nothing
Rarely -- Jaundice, fatigue, myalgia, nausea, vomiting

31

Pathogenesis of Hep C?

Cell-mediated immunopathology damages liver
Microscopically spotted parenchymal cells

32

Sources of Hep C?

Injected Drug Use
Sexual
Transfusion
Mother to Child Transmission (in birth, not breastfeeding)

33

Which needle stick will more likely cause disease -- HCV or HIV?

HCV

34

Treatment for Hep C?

Interferon
Ribavirin
Boceprevir or telaprevir (protease inhibitors)

35

Hepatitis D virus's weakness?

Requires Hep B to steal envelope protein

36

Hep D virus type?

Satellite virus
Enveloped

37

Only protein encoded by Hep D?

Delta antigen

38

Hep D genome?

-ssRNA in covalently closed circle

39

Clinical Presentation of Hep D

Co-infection -- Severe acute disease, potential liver disease, low risk of chronic infection
Super-infection -- Fulminane hepatitis, chronic HDV

40

Control for Hep D?

Prevention of Hep B
Lamivudine

41

Hep E genetics.

+ssRNA, icosahedral, non enveloped

42

Clinical presentation of Hep E

Jaundice, Fatigue, Ab Pain, Loss of Appetite, Tea Urine

43

How is hep E spread?

Fecal-Oral route, esp. in contam. water

44

Parts of the world with prevalent Hep E?

Central/SE Asia, N and W africa, Mexico

45

How to prevent Hep E?

Improved Sanitation