Adrenal and Thyroid Diseases Flashcards Preview

Pharmacology Test II > Adrenal and Thyroid Diseases > Flashcards

Flashcards in Adrenal and Thyroid Diseases Deck (14):
1

What steroids are glucocorticoids?

hydrocortisone/cortisol

2

What drugs are mineralocorticoids?

aldosterone

3

What are the adrenal cortical steroids?

glucocorticoids

mineralocorticoids

adrenal androgens

4

What steroid:

80% bound to CBG 
short acting

hydrocortisol/cortisol

5

What steroid receptor:

widespread expression
immunosuppression
anti-inflammation

glucocorticoid receptor

6

What receptor:

restricted expression
abundant in renal tubules
equal sensitivity to both cortisol and aldosterone

mineralocorticoid receptor

7

What steroid:

does not bind CBG
thus, has short T1/2

aldosterone

mineralcorticoid

8

What disease:

adrenocortical insufficiency
suppression of HPA axis

Addison's Disease

9

What disease:

low cortisol and androgens
normal aldosterone
 

Addison's Disease

10

What disease:

increased urine cortisol
thus increased glucocorticoids
give low dose dexamethasone
 

Cushing's Syndrome

11

What disease:

more prone to infection due to immune suppression
give 5mg/dl of dexamethasone as treatment

Cushing's Syndrome

12

What synthetic steroids:

intermediate acting
increased salt retaining

prednisone
prednilosone

13

What synthetic steroids:

long acting
No CBG binding
minimal salt retaining

dexamethasome

betamethasone

14

What synthetic steroid:

mineralcorticoid

fludocortisone