Central Nervous Depressants Flashcards Preview

Pharmacology Test II > Central Nervous Depressants > Flashcards

Flashcards in Central Nervous Depressants Deck (16):
1

What benzodiazepine is this?

  • long acting
  • good for anxiety
  • suppresses seizures with status epilepticus and cerebral palsy
  • has active metabolites

diazepam (valium)

2

What is a short acting benzo good for:

sleep disorders WITHOUT anxiety

has rapid onset/elimination 

triazolam

3

What are:

short acting hypnotics
have no active metabolites
little anti-anxiety, muscle relaxant or anti-convulsant effect

NBRAs

non-benzodiazepine benzodiazepine receptor agonists

4

What drug is:

relatively selective for type 1 benzodiazepine receptor
rapidly absorbed and eliminated
useful for acute sleep disorder
no hangover
preserves stage 3 sleep
effects on REM sleep rare/inconsistent?

zolipidem (Ambien)

5

What drug is:

for chronic insonia
rapid onset, but longer half-life
binds to all 3 benzo receptor types
no diminished efficacy over 6 month trial?

eszopiclone

(Lunesta)

6

Treatment for benzo or NBRA overdose

fumazenil

7

What drug:

increases GABA binding
decreases glutamate conductance via NMDA receptors
increases serotonin conductance via 5HT3 receptors

ethanol

8

What drug:

decreases reticular system and cerebral cortex 
~40-150mg %
results thiamine deficiency
causes Wernicke-Korsakoff syndrome

ethanol

9

What drug substitutes ETOH  or accidental poisoning?

methanol

10

What drug:

turns to formaldehyde → formic acid
highly toxic → blindness, "snow-storm", coma, death

methanol

11

How do you treat methanol poisoning? (2)

ethanol

fomepizole

12

What drug:

inhibits aldehyde dehydrogenase
inhibits acetate formation
(-) reinforcement of ETOH use

disulfiram

Antabuse

13

What drug:

decreases glutamate neurotransmission
decreases relapse in detox pts?

acamprosate

14

What drug:

GABAB agonist
decreases ETOH withdrawal symptoms
promotes abstinence
decreases anxiety and craving

baclofen

15

What drug:

decreases rewarding effects of ETOH
blocks opioid receptors

naltrexone

16

What drug:

inhibits ETOH dehydrogenase
used for methanol withdrawal

fomepizole