Antipsychotics / Antidepressants Flashcards Preview

Pharmacology Test II > Antipsychotics / Antidepressants > Flashcards

Flashcards in Antipsychotics / Antidepressants Deck (24):
1

What class of drugs:

block dopamine receptors
D2 family of dopamine receptors
Most block alpha1, H1, muscarinic, 5HT2 receptors

antipsychotics

2

What drugs: (2)

typical
expyramidal syndrome
block D2
cause hyperprolactinemia
 

 

chlorpromazine

haloperidol

3

What drug also block alpha1 and 5HT2 more than D2?

chlorpromazine

4

What drugs:

atypical
decreased incidence of extrapyramidal due to rapid dissociation of D2 receptors
can reduce (+/-) symptoms somewhat

clozapine

aripiprazole

5

What atypical drug:

binds to 5HT2 receptor
agranulocytosis up to 3%

clozapine

6

What atypical drug:

partial agonist at D2 and 5HT1
antagonist at 5HT2
activate D2 at low tone and inhibit at high tone
 

apiprazole

7

What is FDA approved for bipolar and schizophrenia?

apiprazole

8

9

Tricyclic antidepressant

imipramine

10

What drug:

not euphoric, dulling
unpleasant when given to non-depressed pt
patient compliance problems

imipramine

tricyclic

11

What drug related to "amine hypothesis"?

imipramine

12

What class is fluoxetine?

SSRI

aka prozac

13

What drug: 

dulling of depressive ideation
selective 5HT uptake inhibitor

fluoxetine

14

What drug:

less antimuscarinic activity →
fewer cardiovascular issues
less pt compliance problems

fluoxetine

15

What MAO-I is:

hydrazine?

nonhydrazine?

phenylzine

tranylcypromine

16

What MAO-I is more of a psychomotor stimulant?

tranycypromine

17

MAO-I →

____NE

____5HT

____DA

 

increases in all

18

19

What drug class side effects include:

orthostatic hypotension
excessive CNS stimulation resulting in tremors
insomnia

MAO-I

20

Side effects of overdose of MAO-I: (4)

agitation

hallucinations

hyperreflexia

convulsions

21

What drug for acute mania and bipolar?

lithium

22

What receptor does lithium inhibit?

GSK - 3B

glycogen synthase kinase - 3 beta

23

What drug:

inositol phosphate metabolism
low margin of safety

lithium

24

What drug:

antimanic
anti-epileptic 

carbamazepine

valproate