Adrenal Cortex Flashcards Preview

PHA2 > Adrenal Cortex > Flashcards

Flashcards in Adrenal Cortex Deck (24):
1

How potent are prednisolone and dexamethosone compared to Cortisol/Hydrocortisone?

Prednisolone = 4x more potent
Dexamethasone = 30x more potent (7.5x more potent than pred)

2

Which steroid requires hepatic activation?

Prednisone needs to be turned into prednisolone at the liver

3

What are the short acting steroids? (

Hydrocortisone, Prednisone, Methylprednisone

4

What the Intermediate acting steroid? (24-48h)

Triamcinolone

5

What are the long acting steroids? (>48h)

Betamethasone, dexamethasone

6

What are the two salt esters?

Sodium phosphate and sodium succinate

7

How do salt esters effect the steroids?

Allow steroids to become soluble for IV injection.

Gives the drugs a faster onset but the same duration as their oral/base steroid.

8

What are the insoluble esters?

Acetate and Acetonide

9

What do insoluble esters do to the steroids?

delays the onset of action and duration to allow for a longer absorption.

duration will be much longer than the oral/base steroid.

10

What steroid cannot become an ophthalmic or dermatologic drug?

Prednisone bc it needs to be change in the liver

11

What is fluticasone used for?

inhaled glucocorticoid for pulmonary disease

12

What is Budesonide used for?

To treat GI disease, works locally at GIT then has high first pass metabolism

13

How are steroids metabolized and excreted?

Widely distributed even to the CNS
highly bound to PP
metabolized to release base steroid
excreted in the urine

14

What drug should NEVER be used with glucocorticoids???

NSAIDS!!!!

15

Side effects of glucocorticoids?

Short term: PU/PD, stress leukogram, decreased T3 measurement
Long term: immune suppression, poor wound healing, hypertension, RISK OF ADDISONS

16

What is the replacement dosing for glucocorticoids?

Pred 0.1-0.22mg/kg/day

17

What is the anti-inflammatory dosing for glucocorticoids?

Pred 0.5-1mg/kg/day

18

What is the Immunosuppressive dosing for glucocorticoids?

Pred 2-4mg/kg/day

19

What is the predominate effect of mineralcorticoids?

essentially aldosterone so Na+ retention.

20

What are the two mineralcorticoids that we know?

Desoxycorticosterone Pivalate (DOCP) and Fludrocortisone

21

How do you give DOCP?

Given IM, no glucocorticoid effects, monitor Na+ and K+ levels

22

How do you give fludrocortisone?

Orally, more potent and has glucocorticoid effect, monitor Na+ and K+ levels

23

T/F Dexamethasone has less mineralcorticoid effect than prednisolone

True.

So when treating with a steroid in a cardiac dysfunction p, you may want to consider using dex over pred

24

What drug is the index corticosteroid with meralcorticoid and glucocorticoid activity of '1'?

Cortisol/Hydrocortisone