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Flashcards in Antibiotic crossword Deck (52):
1

This test can be useful if a full culture and sensitivity cannot be preformed

gram stain

2

The kidney, liver, nervous system, bone marrow, and GI tract are common sites of _____________ with antimicrobials

toxicity

3

A nonselective toxic chemical used topically to kill microorganisms

Antiseptic

4

Technically this term refers to substances secreted by living organisms to inhibit other organisms

Antibiotic

5

Transferable drug resistance encompasses ___________, transduction, and transformation

Conjugation

6

An antibiotic that is effective against a number of gram positive and gram negative organisms is considered ____________ spectrum

Broad

7

When a group of susceptible animals are treated with antibiotics after exposure to a pathogen to prevent disease

Metaphylaxis

8

The Minimum bactericidal concentration is the lowest concentration of antibiotic that will cause this in a bacterium

Death

9

Dead bugs don't _______

Mutate

10

This kind of resistance is present when a bacterium lacks the target of an antibiotic

Intrinsic

11

Potential nephrotoxicity of some antibiotics may be increases by concurrent use of these drugs

Diuretics

12

Mammalian cells lack this, but some antibiotics target it

cell wall

13

Antibiotics that target cell membranes tend to be more ___________

Toxic

14

Both chromosomal mutation and transferable drug resistance represent this type of resistance

acquired

15

Antibiotics that work best when a certain concentration is sustained over a long period of time are considered ____________-dependent antibiotics

Time

16

Antibiotics that work by inhibiting protein synthesis more commonly fall into this category

Bacteriostatic

17

The lowest concentration of an antibiotic that will stop the organism from reproducing is the minimum _____________ concentration

inhibitory

18

Concentration-dependent antibiotics often work best with _______ daily dosing

Once

19

A species in which penicillins should generally not be used orally

Guinea pigs

20

Broad spectrum antibiotic that induces microsomal enzymes to which resistance develops rapidly

Rifampin

21

A macrolide antibiotic that is also used as a GI prokinetic

Erythromycin

22

A carbepenam antibiotic that is used subcutaneously

Meropenem

23

Fluoroquinolones inhibit function of this enzyme

DNA gyrase

24

Acts as a 30s ribosomal subunit and can cause yellow discoloration of the teeth in young animals

Tetracyclines

25

Antibiotics that act as cationic detergents to disrupt cell membranes

Polymyxin B

26

Antimicrobial resistance due to mutation within the microbe

Chromosomal

27

The major toxicities seen with aminoglycosides are ototoxicity and _____________

nephrotoxicity

28

Resistance is due to normal lack of the antimicrobial target in the bacteria

Intrinsic

29

Class of antibiotics that are good against gram-negative bacteria as well as mycoplasma

Fluoroquinolones

30

Pus is so rich in this that it can overcome the action of sulfonamides

PABA

31

A natural penicillin that should not be given IV

Penicillin G

32

Banned in food producing animals due to risk of aplastic anemia in humans

Chloramphenacol

33

One of the most common adverse effects seen with sulfonamide use in dogs

KCS

34

This class is synergistic with penicillins in vivo but incompatible in vitro

Aminoglycosides

35

Streptogramin work on the ______ subunit of the ribosome

50s

36

Clindamycin is a member of this subclass of antibiotics that have good anaerobic activity

lincosamides

37

Specific treatment for tritrichamonas in felines

Ronidazole

38

A last resort antibiotic for MRSA in humans that prevents attachment of the ribosome to mRNA

Linezolid

39

A cell-wall disrupting antibiotic that is often used topically to avoid toxicity

Bacitracin

40

Azithromycin and some other macrolides have extended effects due to accumulation in these

Phagocytes

41

Ormetoprim is an example of a drug that inhibits this

dihydrofolatereductase

42

OFten used with other antibiotics for anaerobic infections and also has immunomodulatory effects

metronidazole

43

The lowest antimicrobial concentration at which bacterial replication is halted

MIC

44

A beta-lactamase inhibitor commonly combined with amoxicillin

Clavulanic acid

45

A first-generation cephalosporin used intramammary for mastitis in cattle

Cephapirin

46

High urinary excretion and more effective in acidic urine

Nitrofurantoin

47

A third generation cephalosporin that is a pro-drug aster converted to the acctive ingredient after absorption

Cefpodoxime

48

A topical antibiotic that can be useful against MRSP/MRSA and used for decolonization in humans

Mupirocin

49

A tetracycline that is usually used orally but can cause esophageal irritation

Doxycycline

50

A macrolide that can cause cardiac issues if given IV

Tilmicosin

51

Novobiocin activity against gram positive bacteria is ______

good

52

Commensal Bacteria can act as a ____________ for resistance genes

Reservoir