Antibiotic crossword

Question 1

This test can be useful if a full culture and sensitivity cannot be preformed

Answer 1

gram stain

Question 2

The kidney, liver, nervous system, bone marrow, and GI tract are common sites of _____________ with antimicrobials

Answer 2

toxicity

Question 3

A nonselective toxic chemical used topically to kill microorganisms

Answer 3

Antiseptic

Question 4

Technically this term refers to substances secreted by living organisms to inhibit other organisms

Answer 4

Antibiotic

Question 5

Transferable drug resistance encompasses ___________, transduction, and transformation

Answer 5

Conjugation

Question 6

An antibiotic that is effective against a number of gram positive and gram negative organisms is considered ____________ spectrum

Answer 6

Broad

Question 7

When a group of susceptible animals are treated with antibiotics after exposure to a pathogen to prevent disease

Answer 7

Metaphylaxis

Question 8

The Minimum bactericidal concentration is the lowest concentration of antibiotic that will cause this in a bacterium

Answer 8

Death

Question 9

Dead bugs don’t _______

Answer 9

Mutate

Question 10

This kind of resistance is present when a bacterium lacks the target of an antibiotic

Answer 10

Intrinsic

Question 11

Potential nephrotoxicity of some antibiotics may be increases by concurrent use of these drugs

Answer 11

Diuretics

Question 12

Mammalian cells lack this, but some antibiotics target it

Answer 12

cell wall

Question 13

Antibiotics that target cell membranes tend to be more ___________

Answer 13

Toxic

Question 14

Both chromosomal mutation and transferable drug resistance represent this type of resistance

Answer 14

acquired

Question 15

Antibiotics that work best when a certain concentration is sustained over a long period of time are considered ____________-dependent antibiotics

Answer 15

Time

Question 16

Antibiotics that work by inhibiting protein synthesis more commonly fall into this category

Answer 16

Bacteriostatic

Question 17

The lowest concentration of an antibiotic that will stop the organism from reproducing is the minimum _____________ concentration

Answer 17

inhibitory

Question 18

Concentration-dependent antibiotics often work best with _______ daily dosing

Answer 18

Once

Question 19

A species in which penicillins should generally not be used orally

Answer 19

Guinea pigs

Question 20

Broad spectrum antibiotic that induces microsomal enzymes to which resistance develops rapidly

Answer 20

Rifampin

Question 21

A macrolide antibiotic that is also used as a GI prokinetic

Answer 21

Erythromycin

Question 22

A carbepenam antibiotic that is used subcutaneously

Answer 22

Meropenem

Question 23

Fluoroquinolones inhibit function of this enzyme

Answer 23

DNA gyrase

Question 24

Acts as a 30s ribosomal subunit and can cause yellow discoloration of the teeth in young animals

Answer 24

Tetracyclines

Question 25

Antibiotics that act as cationic detergents to disrupt cell membranes

Answer 25

Polymyxin B

Question 26

Antimicrobial resistance due to mutation within the microbe

Answer 26

Chromosomal

Question 27

The major toxicities seen with aminoglycosides are ototoxicity and _____________

Answer 27

nephrotoxicity

Question 28

Resistance is due to normal lack of the antimicrobial target in the bacteria

Answer 28

Intrinsic

Question 29

Class of antibiotics that are good against gram-negative bacteria as well as mycoplasma

Answer 29

Fluoroquinolones

Question 30

Pus is so rich in this that it can overcome the action of sulfonamides

Answer 30

PABA

Question 31

A natural penicillin that should not be given IV

Answer 31

Penicillin G

Question 32

Banned in food producing animals due to risk of aplastic anemia in humans

Answer 32

Chloramphenacol

Question 33

One of the most common adverse effects seen with sulfonamide use in dogs

Answer 33

KCS

Question 34

This class is synergistic with penicillins in vivo but incompatible in vitro

Answer 34

Aminoglycosides

Question 35

Streptogramin work on the ______ subunit of the ribosome

Answer 35

50s

Question 36

Clindamycin is a member of this subclass of antibiotics that have good anaerobic activity

Answer 36

lincosamides

Question 37

Specific treatment for tritrichamonas in felines

Answer 37

Ronidazole

Question 38

A last resort antibiotic for MRSA in humans that prevents attachment of the ribosome to mRNA

Answer 38

Linezolid

Question 39

A cell-wall disrupting antibiotic that is often used topically to avoid toxicity

Answer 39

Bacitracin

Question 40

Azithromycin and some other macrolides have extended effects due to accumulation in these

Answer 40

Phagocytes

Question 41

Ormetoprim is an example of a drug that inhibits this

Answer 41

dihydrofolatereductase

Question 42

OFten used with other antibiotics for anaerobic infections and also has immunomodulatory effects

Answer 42

metronidazole

Question 43

The lowest antimicrobial concentration at which bacterial replication is halted

Answer 43

MIC

Question 44

A beta-lactamase inhibitor commonly combined with amoxicillin

Answer 44

Clavulanic acid

Question 45

A first-generation cephalosporin used intramammary for mastitis in cattle

Answer 45

Cephapirin

Question 46

High urinary excretion and more effective in acidic urine

Answer 46

Nitrofurantoin

Question 47

A third generation cephalosporin that is a pro-drug aster converted to the acctive ingredient after absorption

Answer 47

Cefpodoxime

Question 48

A topical antibiotic that can be useful against MRSP/MRSA and used for decolonization in humans

Answer 48

Mupirocin

Question 49

A tetracycline that is usually used orally but can cause esophageal irritation

Answer 49

Doxycycline

Question 50

A macrolide that can cause cardiac issues if given IV

Answer 50

Tilmicosin

Question 51

Novobiocin activity against gram positive bacteria is ______

Answer 51

good

Question 52

Commensal Bacteria can act as a ____________ for resistance genes

Answer 52

Reservoir