Adrenergic Agents Flashcards Preview

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Flashcards in Adrenergic Agents Deck (12):
1

Adrenergic agents

Enhance or reduce activity of the sympathetic division of the autonomic nervous system
Act on adrenergic receptors or neurotransmitters

2

Catecholamines

Adrenergic neurotransmitters
Contain catechol ring and ethylamine moieties
Examples include dopamine, norepinephrine, and epinephrine

3

Metabolism of norepinephrine and epinephrine

Monoamine oxidase and catechol-O-methyltransferase: important enzymes
Major end product: vanillylmandelic acid

4

Adrenergic receptors

Alpha and beta receptors (differ in secondary messengers: alpha- phospholipase C, beta- cAMP)
G-protein coupled receptors

5

Which receptors do what

Constriction: alpha 1 and beta 1
Dilation: alpha 2 and beta 2

6

Structure-activity relationships for catecholamine-like drugs

Adding -OH to alpha carbon gives greater activity in the peripheral nervous system
Increasing size of R group bound to N: increased beta activity and decreased alpha activity
Adding small alkyl groups to beta carbon: less degradation by MAO

7

Phenylethanolamines

Mimic epinephrine
Alpha 1 agonists: vasoconstrictors

8

Clonidine

Alpha 2 agonist: lowers blood pressure

9

Albuterol

Seclective beta 2 agonist: relaxes bronchial muscles (inhaler active ingredient)

10

L-Pseudoephedrine

Indirectly-acting sympathomimetic
Fewer CNS effects than ephedrine
Sudafed: nasal decongestant

11

D-(-)-Ephedrine

Acts on both alpha and beta receptors
CNS stimulant

12

Propranolol

Beta blocker (beta 1 and beta 2)
Treats cardiovascular symptoms, anxiety, and glaucoma (increased pressure in eyes)