Nucleotide Metabolism Flashcards Preview

Med Chem > Nucleotide Metabolism > Flashcards

Flashcards in Nucleotide Metabolism Deck (8):
1

Nucleoside

Base + (deoxy)ribose
Naming: -osine ending for purines, -idine ending for pyrimidines

2

Nucleotide

Base + (deoxy)ribose + one or more Pi

3

Purine biosynthesis

Adenine and guanine are synthesized as adducts of 5-phosphoribosyl 1-pyrophosphate (PRPP)

4

Reduction of ribonucleotides

Ribonucleotides can be reduced to deoxyribonucleotides
NADPH supplies electrons to ribonucleotide reductase (becomes active when reduced), which reduces the ribonucleotide

5

Biosynthesis of dTMP

Thymidine nucleotides are derived from dUMP
dUMP is methylated by thymidylate synthase to form dTMP

6

Salvage reactions

Recycle free bases into nucleotide monophosphates

7

Precursor of purines

Inosine

8

Precursor of thymine and cytosine

Uracil