Drugs Acting on the Renal System Flashcards Preview

Med Chem > Drugs Acting on the Renal System > Flashcards

Flashcards in Drugs Acting on the Renal System Deck (14):
1

Renin-angiotensin system functions

Controls sodium excretion and body fluid volume
Regulates blood pressure

2

Renin

Aspartyl protease made in kidney (responsible for vasopressor response)

3

Angiotensin

Cofactor to renin that stimulates vasoconstriction

4

Angiotensin II

Constricts branches of artery
Regulates aldosterone secretion
Stimulates release of vasopressin from hypothalamus

5

Aldosterone

Controls reabsorption of sodium into the blood stream
Increases sodium levels in plasma
Increases blood volume and vascular resistance
Stimulates production of endothelin (regulates smooth muscle contraction and blood pressure)

6

Vasopressin

Antidiuretic hormone
Released when dehydrated to conserve water

7

Kinins

Vasodilators formed by proteolytic enzymes circulating in the plasma
Control Na and K balance and arterial blood pressure

8

Angiotensin-converting enzyme (ACE)

Nonspecific peptidyldipeptide hydrolase (converts Ang I to Ang II)
Promotes vasoconstriction

9

ACE inhibitors

Inhibit cleavage of Ang I to Ang II

10

ACE inhibitor prodrugs

Treat mild-to-moderate hypertension
Most have a 2-(S)-aminophenylbutyric acid ethyl ester moiety

11

Angiotensin II receptors

AT1, AT2, AT3, AT4
G-protein coupled receptors
AT1: target for managing specific cardiovascular disease (stimulation results in vasoconstriction, etc.)

12

Main effect of angiotensin antagonists

Block stimulation of AT1 by Ang II

13

Renin inhibitors

Inhibit cleavage of angiotensinogen to angiotensin I
Used to manage cardiovascular disease

14

Aldosterone antagonists

Inhibit sodium resorption in distal tubule of nephron, reducing urinary K+ excretion
Results in a weak diuretic effect and decreases cardiac workload