Adrenergic Antagonists Flashcards

0
Q

Phenoxybanzamine type & use

A

irreversible non-selective alpha blocker

tx pheochromocytoma

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1
Q

phentolamine type, effects, and use

A

non-selective alpha blocker
decrease PVR & BP
tx HTN crisis due to pheochromocytoma or MAOI

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2
Q

prazosin type, characteristics, and use

A

a1 blocker
decrease PVR & preload
given 2x/day, risk of orthostatic hypo
tx HTN & BPH

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3
Q

terazosin, doxazosin

type, use, & characteristic

A

a1 blocker
decrease PVR & preload
tx HTN & BPH
similar to prazosin w/ 1x/day dosing

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4
Q

Tamsulosin, alfuzosin

type & use

A

alpha-1a selective
less risk of orthostatic hypotension
tx prostate problems

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5
Q

yohimbine type, effects

A

a2 blocker
increase NE release, increase BP/HR
may interfere w/ clonidine

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6
Q

labetalol type, effects, & use

A

a1, B1, B2 blocker
decrease PVR, prevents tachycardia
used IV for HTN emergencies

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7
Q

carvedilol type, effects, and use

A

a1, B1, B2 blocker
decrease PVR, prevents tachycardia
used CHF & post-MI

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8
Q

propranolol type, characteristics, effects, contraindications

A

B1, B2 blocker
oral, enters CNS
decrease HR & contractility, decreases BP w/ chronic use, decreased renin, glycogenolysis, lipolysis
bronchoconstriction- contraindicated in asthma

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9
Q

timolol type & use, cautions

A

B1, B2 blocker
tx glaucoma
caution in asthma

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10
Q

nadolol type & characteristic

A

non-selective B blocker

no CNS activity

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11
Q

Sotalol type & use

A

non-specific B-blocker

anti-arrhythmic

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12
Q

pindolol, carteolol, penbutol

type, characteristic, use

A

non-selective B-blocker
intrinsic sympathetic activity: may decrease risk for bronchoconstriction or bradycardia
carteolol for glaucoma tx

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13
Q

metoprolol, atenolol, bisprolol type, effects, use

A

B1 blocker
decrease HR and force of contraction
tx HTN or post-MI

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14
Q

betaxolol type & use

A

B1 blocker

tx glaucoma, a safer timolol

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15
Q

nebivolol type, effects, & characteristic

A

B1 blocker
decreases HR & contractile force
produces NO- vasodilation

16
Q

esmolol type & characteristic

A

B1 blocker

short-acting

17
Q

acebutolol type & characteristic

A

B1 blocker

intrinsic sympathetic activity

18
Q

guanethidine type, mechanism, effects

A

indirect acting adrenergic antagonist
inhibits NE release, needs to enter the presynaptic terminal
loss of sympathetic tone occurs over time- postural hypotension, decreased cerebral & coronary blood flow, diarrhea, no ejaculation

19
Q

reserpine type

A

indirect-acting adrenergic antagonist