Anti-arrhythmics

Question 0

Class 1a MOA

Answer 0

preferentially block open or activated Na channels & K channels

slow rise of AP, prolong AP duration, prolong ERP

Question 1

Class IA drugs (2)

Answer 1

Quinidine

Procainamide

Question 2

Quinidine & Procainamide use

Answer 2

atrial & ventricular arrhythmias

Question 3

quinidine adverse effects (4)

Answer 3

reflex tachycardia
paradoxical tachycardia
Torsades des Pointes
EKG changes

Question 4

procainamide rare adverse effect

Answer 4

SLE in slow acetylators

Question 5

Class 1B drug

Answer 5

Lidocaine

Question 6

lidocaine MOA

Answer 6

block inactivated Na channels, shorten the duration of the AP

Question 7

lidocaine use

Answer 7

DOC for acute ventricular arrhythmias

Question 8

lidocaine side effects (4)

Answer 8

least toxic
least negative ionotropic
bradycardia
paresthesias

Question 9

class 1C

Answer 9

flecainide

Question 10

flecainide MOA

Answer 10

bind to all sodium channels

no effect on AP

Question 11

flecainamide uses (3)

Answer 11

supraventricular arrhythmias
life threatening ventricular arrythmias
last ditch effort

Question 12

flecainamide adverse effect

Answer 12

strong pro-arrhythmic effect

Question 13

class 2 (3 drugs)

Answer 13

Propranolol
Acebutolol
Esmolol

Question 14

class 3 (2)

Answer 14

Amiodarone

Sotalol

Question 15

Amiodarone MOA (5)

Answer 15

K+ channel inhibitor
Blocks Na+ channels
B-blocker
Some CCBs
alpha block

Question 16

Amiodarone uses

Answer 16

both atrial & ventricular arrhythmias

Question 17

Amiodarone adverse effects (4)

Answer 17

Prolonged QT
Bradycardia
Pulm fibrosis
Deposited in tissues
Thyroid dysfunction

Question 18

Sotalol MOA (2)

Answer 18

K+ blocker

Non-selective B-blocker

Question 19

Sotalol uses

Answer 19

ventricular & supraventricular arrhythmias

Question 20

Sotalol adverse effects (2)

Answer 20

B-receptor blockade

Torsade de Pointes

Question 21

Class IV (2)

Answer 21

verapamil

diltiazem

Question 22

CCB uses (4)

Answer 22

Re-entrant supraventricular tachycardia
PSVT
A Fib
effects on the SA and AV nodes

Question 23

CCB side effects (3)

Answer 23

negative ionotropic action
constipation
AV block if used w/ B-blockers

Question 24

Adenosine MOA

Answer 24

enhances K+ conductance
inhibits cAMP-induced Ca influx
—> hyperpolarizes everything, restarts the heart

Question 25

Adenosine uses (3)

Answer 25

acute PVST
WPW syndrome
Effective only in re-entry arrhythmias

Question 26

Magnesium uses (4)

Answer 26

tx digitalis induced arrhythmias
DOC Torsades de Pointes
management of seizures, HTN w/ eclampsia

Question 27

Potassium uses (4)

Answer 27

decrease AP duration
decrease conduction
decrease pacemaker rate
decrease pacemaker arrhythmogenesis

Question 28

acute PVST treatment order (3)

Answer 28

Adenosine
Esmolol
CCB (IV)

Question 29

Chronic PSVT tx order (2)

Answer 29

B-blocker

CCB