Anti-arrhythmics Flashcards

(30 cards)

0
Q

Class 1a MOA

A

preferentially block open or activated Na channels & K channels

slow rise of AP, prolong AP duration, prolong ERP

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1
Q

Class IA drugs (2)

A

Quinidine

Procainamide

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2
Q

Quinidine & Procainamide use

A

atrial & ventricular arrhythmias

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3
Q

quinidine adverse effects (4)

A

reflex tachycardia
paradoxical tachycardia
Torsades des Pointes
EKG changes

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4
Q

procainamide rare adverse effect

A

SLE in slow acetylators

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5
Q

Class 1B drug

A

Lidocaine

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6
Q

lidocaine MOA

A

block inactivated Na channels, shorten the duration of the AP

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7
Q

lidocaine use

A

DOC for acute ventricular arrhythmias

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8
Q

lidocaine side effects (4)

A

least toxic
least negative ionotropic
bradycardia
paresthesias

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9
Q

class 1C

A

flecainide

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10
Q

flecainide MOA

A

bind to all sodium channels

no effect on AP

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11
Q

flecainamide uses (3)

A

supraventricular arrhythmias
life threatening ventricular arrythmias
last ditch effort

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12
Q

flecainamide adverse effect

A

strong pro-arrhythmic effect

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13
Q

class 2 (3 drugs)

A

Propranolol
Acebutolol
Esmolol

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14
Q

class 3 (2)

A

Amiodarone

Sotalol

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15
Q

Amiodarone MOA (5)

A
K+ channel inhibitor
Blocks Na+ channels
B-blocker
Some CCBs
alpha block
16
Q

Amiodarone uses

A

both atrial & ventricular arrhythmias

17
Q

Amiodarone adverse effects (4)

A
Prolonged QT
Bradycardia
Pulm fibrosis
Deposited in tissues
Thyroid dysfunction
18
Q

Sotalol MOA (2)

A

K+ blocker

Non-selective B-blocker

19
Q

Sotalol uses

A

ventricular & supraventricular arrhythmias

20
Q

Sotalol adverse effects (2)

A

B-receptor blockade

Torsade de Pointes

21
Q

Class IV (2)

A

verapamil

diltiazem

22
Q

CCB uses (4)

A

Re-entrant supraventricular tachycardia
PSVT
A Fib
effects on the SA and AV nodes

23
Q

CCB side effects (3)

A

negative ionotropic action
constipation
AV block if used w/ B-blockers

24
Adenosine MOA
enhances K+ conductance inhibits cAMP-induced Ca influx ---> hyperpolarizes everything, restarts the heart
25
Adenosine uses (3)
acute PVST WPW syndrome Effective only in re-entry arrhythmias
26
Magnesium uses (4)
tx digitalis induced arrhythmias DOC Torsades de Pointes management of seizures, HTN w/ eclampsia
27
Potassium uses (4)
decrease AP duration decrease conduction decrease pacemaker rate decrease pacemaker arrhythmogenesis
28
acute PVST treatment order (3)
Adenosine Esmolol CCB (IV)
29
Chronic PSVT tx order (2)
B-blocker | CCB