Adrenergic Pharmacology Flashcards Preview

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Flashcards in Adrenergic Pharmacology Deck (12):
0

Norepinephrine is the primary neurotransmitter at the sympathetic postganglionic neuron- effector cell synapses except in

Eccrine sweat glands
Vasodilator sympathetic fibers in skeletal muscle

1

Tyrosine --> levodopa by tyrosine hydroxylase inhibited by

Metyrosine
Then levodopa decarboxylated to dopamine and hydroxylated to norepinephrine

2

Storage of NE

Reserpine Inhibits vesicular transport
MAOIS increase stores of NE and dopamine

3

Calcium enters interacts with SNARE inhibited by

Guanethedine
Promoted by amphetamines and tyramine

4

Termination via reuptake via NET DAT

Inhibited by cacaine and TCAs

5

Termination by metabolizing into metanephrines and VMA

Inhibited by MAOIs and COMTis

6

Synthesis inhibitors
Cholinergic-adrenergic

HEMICHOLINIUM - Metyrosine

7

Storage inhibitors
Cholinergic-adrenergic

VESAMICOL - Reserpine

8

Release inhibitors
Cholinergic-adrenergic

Botulinum - guanethidine

9

Reuptake inhibitors
Cholinergic-adrenergic

Metabolism neostigmine - MAOIs and COMTis
Reuptake - none - cocaine TCA

10

Adrenoceptors

a1 - smooth muscle constriction
a2 - nerve endings and smooth muscles
b1 - heart and JGA
b2 - smooth muscle dilation, lungs

11

Miscellaneous adrenoceptors

b3 - fat cells stimulates lipolysis
D1 - renal and splanchnic
D2 - inhibits adenylyl cyclase in nerve terminals