Autonomic Pharmacology Flashcards Preview

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Flashcards in Autonomic Pharmacology Deck (27):
0

Autonomic nervous system

Involuntary, unconscious, automatic portion of nervous system.

1

Major divisions

PANS rest and digest
SANS fight or flight

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PANS

CN 1973, III, VII, IX, X
sacral spinal cord
PLASMA para, long preganglionic, acetylcholine, short postganglionic, muscarinic, acetylcholine

3

PANS Action

Bradycardia, secretions are increased, sphincters relaxed
point = erection

4

SANS

Thoracic and lumbar spinal cord
Tachycardia, lipolysis b3, gluconeogenesis, glycogenolysi
shoot = ejaculation

5

Acetylcholine synthesis

Choline transport inhibited by HEMICHOLINIUM

6

Ach storage

Inhibited by VESAMICOL

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Termination of Ach

Inhibited by indirect acting cholinomimetics
CARBAMATES and ORGANOPHOSPHATE

8

Direct acting cholinomimetics muscarinic

Betanechol and pilocarpine
Activates M3 receptors.
Betanechol bowel and bladder atony
Pilocarpine glaucoma, Sjogren and Sicca

9

Direct acting cholinomimetics nicotinic

Nicotine/ Varenicline

10

Muscarinic toxicity

Bronchoconstriction, excessive GI and GU secretions, vasodilation

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Nicotinic toxicity

Convulsions, fasciculations, paralysis, CNS depression

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Indirect acting cholinomimetics work on acetylcholinesterase

Edrophonium, neostigmine, rivastigmine

13

Neostigmine

Pyridostigmine
Physostigmine can cross BBB lipid soluble
Treatment of Ogilvie, Myasthenia Gravis

14

Rivastigmine

Galantamine, Donepezil, Tacrine
For Alzheimer's

15

Tensilon test

Diagnosis of myasthenia Gravis uses edrophonium

16

Antidote for organophosphate poisoning

Atropine - cholinergic antagonist, muscarinic competitive antagonist
Pralidoxime - regenerates cholilnesterase, golden Period 6-8 hours

17

Cholinoceptor blocker/antagonist, muscarinic

Atropine, benztropine, ipratropium, scopolamine

18

Atropine

Homatropine, cyclopentolate, tropicamide

19

Benztropine. Can also restore neurotransmitter balance in basal ganglia. May be used for Parkinson's

Biperiden, trihexyphenidyl, achinitone

20

Ipratropium. Also prevents vagal-stimulated bronchoconstriction. COPD less likely to produce tachycardia and cardiac arrhythmia

Tiotropium

21

Scopolamine

Antagonizes histamine and serotonin, used for motion sickness

22

Atropine toxicity

HOT as a hare, DRY as a bone, RED as a beet, BLIND as a bat, MAD as a hatter

23

Do not give cholinergic antagonist if

Benign prostatic hyperplasia
Acute-angle closure glaucoma
Use with caution in infants, may lead to hyperthermia. Due to decreased sweating

24

Cholinergic antagonist nicotinic

Hexamethonium.
Trimethapan
WOF postural hypotension

25

Nondepolarizing neuromuscular blocker

Tubocurarine, pancuronium, atracurium, vecuronium

26

Depolarizing neuromuscular blocker

Succinylcholine