Autonomic Pharmacology

Question 0

Major divisions

Answer 0

PANS rest and digest

SANS fight or flight

Question 1

Autonomic nervous system

Answer 1

Involuntary, unconscious, automatic portion of nervous system.

Question 2

PANS

Answer 2

CN 1973, III, VII, IX, X
sacral spinal cord
PLASMA para, long preganglionic, acetylcholine, short postganglionic, muscarinic, acetylcholine

Question 3

PANS Action

Answer 3

Bradycardia, secretions are increased, sphincters relaxed

point = erection

Question 4

SANS

Answer 4

Thoracic and lumbar spinal cord
Tachycardia, lipolysis b3, gluconeogenesis, glycogenolysi
shoot = ejaculation

Question 5

Acetylcholine synthesis

Answer 5

Choline transport inhibited by HEMICHOLINIUM

Question 6

Ach storage

Answer 6

Inhibited by VESAMICOL

Question 7

Termination of Ach

Answer 7

Inhibited by indirect acting cholinomimetics

CARBAMATES and ORGANOPHOSPHATE

Question 8

Direct acting cholinomimetics muscarinic

Answer 8

Betanechol and pilocarpine
Activates M3 receptors.
Betanechol bowel and bladder atony
Pilocarpine glaucoma, Sjogren and Sicca

Question 9

Direct acting cholinomimetics nicotinic

Answer 9

Nicotine/ Varenicline

Question 10

Muscarinic toxicity

Answer 10

Bronchoconstriction, excessive GI and GU secretions, vasodilation

Question 11

Nicotinic toxicity

Answer 11

Convulsions, fasciculations, paralysis, CNS depression

Question 12

Indirect acting cholinomimetics work on acetylcholinesterase

Answer 12

Edrophonium, neostigmine, rivastigmine

Question 13

Neostigmine

Answer 13

Pyridostigmine
Physostigmine can cross BBB lipid soluble
Treatment of Ogilvie, Myasthenia Gravis

Question 14

Rivastigmine

Answer 14

Galantamine, Donepezil, Tacrine

For Alzheimer’s

Question 15

Tensilon test

Answer 15

Diagnosis of myasthenia Gravis uses edrophonium

Question 16

Antidote for organophosphate poisoning

Answer 16

Atropine - cholinergic antagonist, muscarinic competitive antagonist
Pralidoxime - regenerates cholilnesterase, golden Period 6-8 hours

Question 17

Cholinoceptor blocker/antagonist, muscarinic

Answer 17

Atropine, benztropine, ipratropium, scopolamine

Question 18

Atropine

Answer 18

Homatropine, cyclopentolate, tropicamide

Question 19

Benztropine. Can also restore neurotransmitter balance in basal ganglia. May be used for Parkinson’s

Answer 19

Biperiden, trihexyphenidyl, achinitone

Question 20

Ipratropium. Also prevents vagal-stimulated bronchoconstriction. COPD less likely to produce tachycardia and cardiac arrhythmia

Answer 20

Tiotropium

Question 21

Scopolamine

Answer 21

Antagonizes histamine and serotonin, used for motion sickness

Question 22

Atropine toxicity

Answer 22

HOT as a hare, DRY as a bone, RED as a beet, BLIND as a bat, MAD as a hatter

Question 23

Do not give cholinergic antagonist if

Answer 23

Benign prostatic hyperplasia
Acute-angle closure glaucoma
Use with caution in infants, may lead to hyperthermia. Due to decreased sweating

Question 24

Cholinergic antagonist nicotinic

Answer 24

Hexamethonium. Trimethapan WOF postural hypotension

Question 25

Nondepolarizing neuromuscular blocker

Answer 25

Tubocurarine, pancuronium, atracurium, vecuronium

Question 26

Depolarizing neuromuscular blocker

Answer 26

Succinylcholine