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Flashcards in Drugs For Hypertension Deck (30):
0

Target BP NO comorbids

<140/90

1

Target BP with DM

< 130/80

2

Diuretics

Hydrochlorothiazide, furosemide

3

Hydrochlorothiazides

Chlorthalidone, indapamide, metolazone
Thiazides inhibits nacl transporter in distal convoluted tubule,reduces calcium excretion.
1st line HPN, hypercalciuria, , nephrogenic diabetes insipidus

4

Thiazides toxicity

Hyper GLUC
-glycemia, lipidemia, uricemia, calcemia

5

Furosemide

Bumetanide, torsemide, ethacrynic acid - has no sulfa group
Loop diuretics, inhibits nak2cl transporter in thick ascending limb LOH. INCREASED diuresis and calcium excretion
Use in heart failure, pulmonary edema, hypercalcemia

6

Sympathoplegics

Decrease TPR, HR

7

CNS sympathetic outflow blockers

Clonidine, methyldopa

8

Ganglion blockers

Hexamethonium, trimethaphan
Competetively blocks Nn nicotinic Ach receptors

9

Nerve terminal blockers

Reserpine, guanethidine
Blocks vesicular mono amine tranporter (VMAT), inhibits NE release
WOF Suicidal ideation

10

Adrenergic blockers

PRAZOSIN, propranolol

11

HPN control in pheochromocytoma

Phenoxybenzamine, PHENTOLAMINE, labetalol

12

Older vasodilators

Hydralazine, minoxidil,

13

Hydralazine

Intercellular calcium metabolism. Relaxes arteriolar smooth muscle, causes vasodilation, decreases afterload.
WOF reflex tachycardia

14

Drug-induced lupus

HIPP to have lupus
HYDRALAZINE, Isoniazid, Procainamide, Penicillamine

15

Minoxidil

Opens K+ channels in vascular smooth muscle, hyperpolarization, muscle relaxation, vasodilation
Causes hypertrichosis by stimulating hair follicles to differentiate into growth follicles, anagen phase.

16

Calcium channel blockers

Verapamil, nifedipine,

17

Verapami

Diltiazem, NONDIHYDROPYRIDINE ccb.blocks voltage gated l-type calcium channels. Cardiac > vascular
Gingival hyperplasia pretibial edema

18

Nifedipine

Amlodipine, Felodipine, nicardipine, nisoldipine,
DIHYDROPYRIDINE ccb. Vascular > cardiac
Decreases pre and afterload
Pretibial edema

19

Parenteral vasodilators

Nitroprusside, fenoldepam

20

Nitroprusside

Relaxes venous and arteriolar smooth muscle
WOF cyanide toxicity due to increased GMP NO release

21

Antidote for cyanide toxicity

Amyl nitrite

22

Antidote methhemoglobinemia

Methylene blue

23

Angiotensin antagonists

ACEI's, ARB's, Renin antagonists

24

ACEI's

CAPTOPRIL, enalapril, benazepril, fosinopril, lisinopril, quinapril, ramipril, trandolapril
Inhibit ACE thus inhibits Angiotensin II, decreases aldosterone.
Delays progression of diabetic nephropathy

25

Diabetes and ACEIs

Decrease albumin excretion slows progression from micro to macro-albuminuria.
RENOPROTECTIVE

26

ARBs

LOSARTAN, candesartan, valsartan, irbesartan, eprosartan, telmisartan
Blocks angiotensin at1 receptors. Decreases aldosterone secretion.
Slows ventricular remodeling, increases survival heart failure

27

LOSARTAN

Delays progression of diabetic nephropathy
Slows ventricular remodeling and increases survival in heart failure

28

ACEIs and Arbs cause

Hyperkalemia.
Reduce aldosterone levels, lead to potassium retention.

29

Renin antagonists

Aliskiren Alis ka renin!!!
Prevents conversion of angiotensinogen to angiotensin1