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Flashcards in Antiarrhythmics Deck (31):
0

Singh-Vaughan Williams classification

Class 1 sodium channel blockers
Class 2 beta blockers
Class 3 potassium channel blockers
Class 4 calcium channel blockers

1

Class 1 antiarrhythmic

Has local anesthetic activity
Acts on phase 0 of cardiac action potential

2

Class 1a

Prolongs AP duration

3

Class 1b

Shortens AP duration

4

Group 1c

no effect on AP

5

MOA group 1

Block conduction in ischemic and depolarized cells.
Slows down or abolishes abnormal pacemakers

6

Most selective class 1 group to ischemic tissue

Class 1b

7

Use dependent for class 1

Selective for tissues that are frequently depolarizing.

8

State dependent class1 antiarrhythmic

Selective for tissues that are relatively depolarized during rest

9

Class 1a drugs

Procainamide, disopyramide, quinidine
I Am the Quin who PROClaimed DISO's pyramide

10

Procainamide

Blocks Ina and some Ik channels.
Slowed conduction velocity and pacemaker activity.
Post MI arrhythmia
WOF lupus like syndrome

11

Disopyramide

Marked antimuscarinic effects.
Atropine like effects

12

Quinidine

Can be used in malaria.
WOF cinchonism - headache, vertigo, tinnitus

13

Class 1b antiarrhythmic drugs

I Buy MEXIcan TOCAs from LIly
Mexiletine, tocainide, lidocaine

14

Ib selective for

Ischemic or depolarized Purkinje and ventricular tissue.

15

Lidocaine

Mexiletine, tocainide, phenytoin
DOC for ventricular arrhythmias post MI. or digoxin induced arrhythmia.
Lidocaine is the least cardiotoxic

16

Drugs causing agranulocytosis

CCCAPPIT!!!
Clozapine, Co-trimoxazole, Colchicine, Aminopryrine, Phenylbutazone, PTU, Indomethacin, Tocainide

17

Class 1c drugs

Flecainide, propafenone, encainide, moricizine
Used for refractory arrhythmias
CONTRAINDICATED post MI

18

WPW

Procainamide and Amiodarone
Class 1a

19

Class2 antiarrhythmic

Beta blockers reduces cAMP
reduction of both na and ca channels
Prolonged PR intervals
Acts on phase 4

20

ESMOLOL

SVT

21

Class 2 with class 3 properties

Sotalol

22

Thyrotoxic arrhythmias

ESMOLOL

23

Class 3

Acts on phase 3.
Prolongs AP duration.blocks potassium no repolarization
Increase QT Interval

24

Class 3 drugs

Dofetilide, sotalol, Amiodarone, ibutilide
AIDS

25

Dofetilide and ibutilide

WOF torsades de pointes

26

Sotalol

WOF sinus Brady, asthma

27

Amiodarone/ dronedarone

Marked prolonged AP and RP.
Off label refractory arrhythmias. Most efficacious.
WOF microcrystalline deposits in cornea and skin

28

Amiodarone toxicity

Pulmonary fibrosis, Paresthesia, Tremor, Thyroid dysfunction, Corneal deposits, Skin deposits

29

Class 4 drugs

Verapamil, diltiazem
Calcium dependent like AV node
Increased PR interval can use in SVT
NON-DIHYDROPYRIDINE

30

Adenosine

Increase diastolic Ik of AV Node
DOC paroxysmal SVT