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Flashcards in Adrenoceptor Blocker Deck (17):
0

Nonselective alpha blockers

Phenoxybenzamine, PHENTOLAMINE

1

Phenoxybenzamine

Irreversibly blocks a adrenergic a1>a2
Pre-operative treatment pheochromocytoma

2

PHENTOLAMINE

Reversibly blocks a adrenergic receptors a1>a2
Post-surgical therapy for pheochromocytoma
Antidote for rebound hypertension to clonidine

3

Selective a1 blocker

PRAZOSIN, doxazosin, terazosin, tamsulosin, silodosin
BPH HPN
Give at night to prevent orthostatic hypotension

4

Non-selective beta blocker.

Propranolol, pindolol, timolol, labetalol, carvedilol, nadolol.
Reduces renin release.
Adrenergic antagonist

5

Beta-blocker with combined a and b blockade. Can mask symptoms of hypoglycemia.

Labetalol

6

Beta-blockers with ISA intrinsic sympathomimetic activity
Partial agonist, in asthma patients less likely to cause bronchospasm.

Pindolol, acebutalol

7

Beta-blocker with longest half-life

NADOLOL NAsa DOLOL

8

Beta blocker with shortest half life

ESMOLOL esmall

9

Selective beta1 blocker

BeEs Ace MeAt
Betaxolol, ESMOLOL, Acebutolol, metoprolol, ATENOLOL
SVT ESMOLOL only

10

Flow of aqueous humor

Ciliary body --> posterior chamber --> anterior chamber angle --> pupil --> anterior chamber --> trabecular meshwork --> canal of schlemm --> uveoscleral veins

11

SANS on pupil

Dilates

12

PANS on pupil

Constricts

13

Decreases aqueous secretion from ciliary body

Timolol, mannitol, apraclonidine, acetazolamide, dorzolamide

14

Ciliary muscle contraction, opens trabecular meshwork, increases outflow

Pilocarpine, physostigmine

15

Increases aqueous outflow through canal schlemm

Latanoprost

16

Increased outflow from uveoscleral veins

Epinephrine