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Flashcards in Adrenergics Deck (82):
1

Tissues and actions of Alpha 1 receptors

Vascular smooth muscle contraction
Pupillary dilator muscle contraction

2

Tissues and actions of Alpha 2 receptors

Inhibition of transmitter release in adrenergic and cholinergic nerve terminals

3

Tissues and action of Beta 1 receptors

Stimulation of the rate and force of cardiac contraction
Stimulation of renin release from the JGA

4

Tissues and action of Beta 2 receptors

Relaxation of respiratory, uterine and vascular smooth muscle
Act on somatic motor nerve terminals and can cause tremor

5

Tissues and action of Dopamine 1 receptors

Renal and other splanchnic blood vessel relaxation

6

What G-protein class is coupled with α1 adrenergic receptors?

Gq --> activate PLC to produce IP3 and DAG and increase intracellular Ca2+ levels

7

What G-protein class is coupled with α2 adrenergic receptors?

Gi --> decrease NT release by inhibition of Adenylyl cyclase

8

What G-protein class is coupled with β1 adrenergic receptors?

Gs --> activate adenylyl cyclase to increase cAMP
Responsible for increased Ca current in phase 4 depolarization of the heart --> increased HR

9

Epinephrine mechanism of action

α and β agonist

10

Epinephrine indication

anaphylaxis
shock
cardiac arrest
heart block

11

Norepinephrine mechanism of action

α and β1 agonist

12

Norepinephrine indication

acute hypotension due to shock

13

Dopamine mechanism of action

D1 and β-agonist at low infusion rate
α agonist at higher infusion rate

14

Dopamine indication

Cardiogenic shock

15

Isoproterenol mechanism of action

nonselective β agonist

16

Isoproterenol indication

transient heart block

17

Dobutamine mechanism of action

β1 agonist (selective)

18

Dobutamine indication

Short term Rx for low cardiac contractility (CHF or cardiogenic shock)

19

Terbutaline mechanism of action

β2 agonist (selective)

20

Terbutaline indication

Prevent and reverse bronchospasm in asthma, bronchitis and emphysema

21

Albuterol mechanism of action

β2 agonist (selective)

22

Albuterol indication

Bronchial smooth muscle relaxation

23

Phenylephrine mechanism of action

α1 agonist

24

Phenylephrine indication

Pressor agent for anesthesia, nasal congestion
Pupllary dilation
Supraventricular tachycardia

25

Clonidine mechanism of action

α2 agonist

26

Clonidine indication

Hypertension

27

Amphetamine mechanism of action

Indirect sympathomimetic

28

Amphetamine indication

ADHD

29

Methylphenidate mechanism of action

Indirect sympathomimetic

30

Methylphenidate indication

ADHD

31

Ephedrine mechanism of action

Indirect sympathomimetic

32

Ephedrine indication

Pressor agent with anesthesia

33

Pseudoephedrine mechanism of action

Indirect sympathomimetic

34

Pseudoephedrine indication

Nasal decongestant

35

Tyramine mechanism of action

Displaces NE

36

Tyramine indication

Not therapeutic

37

Propranolol mechanism of action

β blocker

38

Propranolol indication

Hypertension
Angina due to atherosclerosis
Myocardial infarction

39

Timolol mechanism of action

β blocker

40

Timolol indication

Glaucoma

41

Nadolol mechanism of action

β blocker

42

Nadolol indication

Long term angina
Hypertension

43

Atenolol mechanism of action

β1 blocker

44

Atenolol indication

Hypertension
Angina
Myocardial infarction

45

Metoprolol mechanism of action

β1 antagonist

46

Metoprolol indication

Hypertension
Long term angina Rx

47

Pindolol mechanism of action

β-antagonist (partial agonist activity)

48

Pindolol indication

Hypertension

49

Esmolol mechanism of action

β1 blocker

50

Esmolol indication

Supraventricular tachycardia

51

Phenoxybenzamine mechanism of action

α blocker

52

Phenoxybenzamne indication

Pheochromocytoma

53

Phentolamine mechanism of action

α blocker

54

Phentolamine indication

Test for pheochromocytoma
Rx for pheochromocytoma before surgery

55

Prazosin mechanism of action

α1 blocker

56

Prazosin indication

Hypertension

57

Doxazosin mechanism of action

α1 antagonist

58

Doxazosin indication

Prostatic hyperplasia
Hypertension

59

Terazosin mechanism of action

α1 blocker

60

Terazosin indication

Prostatic hyperplasia
Hypertension

61

Rank the half lives of the β blockers from fastest to slowest

Propranolol = Timolol > Nadolol

62

Which β1 blocker has the shortest half life?

Esmolol has the shortest half life of the β1 blockers (9 min, compared to hours for atenolol and metoprolol)

63

Epinephrine toxicity

Arrhythmias

64

Norepinephrine toxicity

Ischemia due to over-vasoconstriction

65

Norepinephrine contraindication(s)

Preexisting vasoconstriction/ischemia

66

Dopamine toxicity

Low blood pressure
Ischemia

67

Isoproterenol toxicity

Tachyarrhythmias

68

Isoproterenol contraindications

Angina w/ arrhythmias

69

Dobutamine toxicity

Hypotension (β2 effect at high doses)

70

Terbutaline and albuterol toxicity

Tachycardia (β1)
Muscle tremor (β2)
Tolerance (β2)

71

Phenylephrine toxicity

Hypertension

72

Clonidine toxicity

Dry mouth
Hypertensive crisis (after acute withdrawal)

73

Toxicity associated with indirect acting sympathomimetics

Tachycardia

74

Contraindications for indirect acting sympathomimetics

Rx with MAO inhibitors within 2 weeks

75

Toxicity of non-selective β blockers

Bronchospasm
Masking symptoms of hypoglycemia
Bradycardia

76

Contraindications of non-selective β blockers

*ASTHMA*
Sinus bradycardia
2nd and 3rd degree heart block
Cardiogenic shock

77

Toxicity of β1 blockers

Hypotension
Bradycardia

78

Contraindications of β1 blockers

Sinus bradycardia
2nd and 3rd degree heart block
Cardiogenic shock

79

Toxicity of Pindolol

Hypotension

80

Contraindications of Pindolol

Sinus bradycardia
2nd and 3rd degree heart block
Cardiogenic shock

81

Toxicity of non selective α blockers

Prolonged hypotension
Reflex tachycardia

82

Toxicity of α1 blockers

Orthostatic hypotension