Neuromuscular Relaxants Flashcards Preview

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Flashcards in Neuromuscular Relaxants Deck (29):
1

Succinylcholine mechanism of action

Depolarization blockade of muscle nicotinic receptors

2

Succinylcholine indication

Tracheal intubation
Electroconvulsive therapy

3

Effect of cholinesterase inhibitors on succinylcholine blockade within 4-8 min

Augmented blockade

4

Side effects of succinylcholine

Non-analgesic
Apnea
Muscle pain
Arrhythmia, hypertension and bradycardia
Hyperkalemia
Malignant hyperthermia

5

Pancuronium mechanism of action

Non-depolarizing blockade of muscle nicotinic receptors

6

Pancuronium indication

Adjuvant in surgical anesthesia
Abdominal wall relaxtion
Orthopedic procedures

7

D-tubocurarine mechanism of action

Non-depolarizing blockade of muscle nicotinic receptors

8

D-tubocurarine indication

Prototype drug
Only used in lethal injection

9

Rocuronium mechanism of action

Non-depolarizing blockade of muscle nicotinic receptors

10

Rocuronium indication

Intubation
Muscle relaxation during surgery or ventilation

11

Mivacurium mechanism of action

Non-depolarizing blockade of muscle nicotinic receptors

12

Mivacurium indication

Intubation
Muscle relaxation during surgery or ventilation in patients with RENAL FAILURE

13

Vecuronium mechanism of action

Non-depolarizing blockade of muscle nicotinic receptors

14

Vecuronium indication

Adjuvant in surgical anesthesia
Abdominal wall relaxation, orthopedic procedures

15

Which non-depolarizing NMJ blockade drug would you use in a patient with liver failure?

Pancurium, because it is primarily eliminated by the kidney

16

Baclofen mechanism of action

GABA B agonist
Inhibits neurotransmitter release from skeletal muscle sensory afferent

17

Baclofen indication

Muscle spasticity associated with MS or spinal cord injury

18

Baclofen side effects

Drowsiness

19

Diazepam mechanism of action

Benzodiazepine receptor agonist
"GABA mediated presynaptic inhibition"

20

Diazepam indication

Muscle spasm due to local injury
Muscle spasticity due to loss of inhibitory input (cerebral palsy)

21

Tizanidine mechanism of action

centrally acting α2 agonist
"TWOz-α-nidine"

22

Tizanidine indication

Muscle spasticity due to spinal cord injury or MS

23

Side effect of benzodiazepines

Drowsiness

24

Tizanidine side effects

Drowsiness, hypotension

25

Dantrolene mechanism of action

Uncouples excitation contraction of skeletal muscle by blocking ryanodine receptors

26

Dantrolene indication

Muscle spasm
Malignant hyperthermia

27

Dantrolene side effects

Muscle weakness
Sedation

28

What are the two classes of neuromuscular blockers?

1) Non-depolarizing agents (curare type)
2) Depolarizing agents (succinylcholine)

29

How do you reverse the effect of non-depolarizing muscle relaxants?

Administer neostigmine (AChE inhibitor to increase [ACh] in synapses) and Glycopyrrolate (to minimize the muscarinic effects of neostigmine)