Cholinergics Flashcards Preview

Pharmacology > Cholinergics > Flashcards

Flashcards in Cholinergics Deck (44):
1

Nicotine mechanism of action

Activation of neuronal nicotinic receptors

2

Nicotine indication

Withdrawal symptoms of smoking cessation

3

Succinyllcholine mechanism of action

Depolarizing block of muscle nicotinic receptors

4

Acetylcholine mechanism of action

Nicotinic and muscarinic agonist

5

Acetylcholine indication

No therapeutic use because of rapid degradation

6

Methacholine mechanism of action

Muscarinic agonist

7

Methacholine indication

Diagnosis of subclinical asthma
Test for severity of asthma

8

Carbachol mechanism of action

Muscarinic and nicotinic receptor agonist

9

Carbachol indication

Miotic agent in ocular surgery
Reduces pressure following ocular surgery

10

Bethanechol mechanism of action

Muscarinic agonist

11

Bethanechol indication

Urinary retention
Bladder atony

12

Pilocarpine mechanism of action

Muscarinic agonist

13

Pilocarpine indication

Dry mouth from head/neck radiation or Sjogrens syndrome
Narrow angle glaucoma

14

Neostigmine mechanism of action

AchE inhibitor

15

Neostigmine indication

Myasthenia gravis
Reversal of neuromuscular block

16

Edrophonium mechanism of action

AchE inhibitor

17

Edrophonium indication

diagnosis of myasthenia gravis
Reversal of neuromuscular block

18

Physostigmine mechanism of action

Reversible AchE inhibitor

19

Physostigmine indication

Delirium from anticholinergic drugs
Glaucoma

20

Donepezil mechanism of action

Reversible AchE inhibitor

21

Deonepezil indication

Alzheimers disease

22

Pralidoxime mechanism of action

Peripheral AchE reactivator

23

Pralidoxime indication

Respiratory muscle weakness from organophosphate poisoning

24

Echothiophate mechanism of action

Irreversible AchE inhibitor

25

Echothiophate indication

Open angle glaucoma

26

Atropine mechanism of action

Muscarinic antagonist

27

Atropine indication

Excess secretions during surgery
Increased frequency/urgency of urination with cystitis
Hypertonic gut
Organophosphate poisoning
Bradycardia

28

Scopolamine mechanism of action

Muscarinic antagonist

29

Scopolamine indication

Motion sickness
Anti-saliagogue in surgery

30

Glycopyrrolate mechanism of action

Muscarinic receptor antagonist

31

Glycopyrrolate indication

Protect against excessive muscarinic activation during reversal of neuromuscular block
Anti-saliagogue

32

Toxicity of methacholine

bronchiole constriction

33

Contraindication of methacholine

β blockers will prevent reversal of constriction

34

Carbachol toxicity

Excessive muscarinic activation (bronchoconstriction, reduced cardiac condition)

35

Bethanechol toxicty

Bradycardia, bronchoconstriction
(Less effect on M2 receptors than carbachol)

36

Bethanechol contraindications

asthma, peptic ulcers, bradycardia

37

Pilocarpine toxicity

Excessive muscarinic activation (slowed AV conduction)
Hypotension
Excessive salivation
Bronchoconstriction

38

Neostigmine toxicity

muscarinic and nicotinic excess

39

Edrophonium toxicity

bradycardia
cardiac standstill
Excess can appear like myasthenia gravis

40

Edrophonium contraindications

intestinal blockade or urinary obstruction

41

Physostigmine side effects

Convulsions, respiratory and CV depression
due to increased ACh at muscarinic and nicotinic receptors

42

Physostigmine contraindications

asthma, CV disease, intestinal obstruction

43

Organophosphate toxicity

DUMBBELLS
diarrhea, urination, miosis, bradycardia, bronchorrea, emesis, lacrimation, salivation

44

Succinylcholine contraindications

Patients with Hx of familial hyperthermia or skeletal muscle myopathies