[ALL] Flashcards
(36 cards)
1
Q
A
Child
commonest
2
Q
A
Downs Syndrome
3
Q
A
T
B
4
Q
A
Antibody production
5
Q
A
memory B cells
specific antibody production
6
Q
A
CD4+
CD8+
7
Q
A
Mature in Thymus
8
Q
A
T helper
9
Q
A
CD4+ (T helper)
10
Q
A
Cytokines
11
Q
A
Cytotoxic T cells
12
Q
A
1
13
Q
A
all nucleated
14
Q
A
x-rays
15
Q
A
immature
16
Q
A
bone marrow failure
17
Q
A
reduced WCC
18
Q
A
reduced platelet count
19
Q
A
infection
bleeding
anaemia
20
Q
A
tissue infiltration
21
Q
A
hepatosplenomegaly
lymphadenopathy
cranial nerve palsys
meningisms
22
Q
A
tissue infiltration
23
Q
A
Pneumocystis jirovecii
24
Q
A
Blood film
CXR - lymphadenopathy
LP - CNS involvement
25
[ALL]: what CNS involvement may be seen (2)
Meningisms
| CN palsy
26
[ALL]: Tx: what may cause renal damage as a result of therapy?
Tumour lysis syndrome
| K+ and urate release
27
[ALL]: Tx: remission induction? (2)
Vincristine
| Prednisolone
28
[ALL]: Tx: how does vincristine?
arrests mitosis (inhibits microtubules assembly)
29
[ALL]: Tx: what may be used for CNS prophylaxis?
Methotrexate
30
[ALL]: Tx: What is the maintenence chemotherapy regimens? (3)
```
mercaptopurine (daily)
+
Methotrexate (weekly)
+
Vincristine + Prednisolone
```
31
[ALL]: Tx: how does mercaptopurine work?
immunosuppressive - competes for purine.
32
[ALL]: Tx: what surgical intervention can children undertake?
matched related allogeneic marrow transplant
33
[ALL]: Tx: at what stage in their therapy can children undergo matched related allogeneic marrow transplant
after 1st remission
34
[ALL]: What is the definition of 'haematological remission'? (3)
no leukaemia in blood
normal/recovering blood count
<5% blasts in recovering marrow
35
[ALL]: roughly what is the cure rate in children
70-90%
36
[ALL]: is rare to see in ....
adults
