Flashcards in [b12/pernicious] Deck (28):
[b12/pern]: where is B12 found (3)
[b12/pern]: body stores of B12 are?
[b12/pern]: B12 is absorbed bound to what?
[b12/pern]: synthesis of DNA is blocked in B12 deficiency due to inability to synthesis
[b12/pern]: what 3 things can contribute to stomach mediated malabsorption
[b12/pern]: [b12/pern]: what 5 things can contribute to terminal ileum mediated malabsorption
[b12/pern]: B12 deficiency may present with what 2 facial features
glossitis (beefy-red sore tongue)
[b12/pern]: Sub-acute combined degeneration of the spinal cord presents with
[b12/pern]: what is SACDSC due to
[b12/pern]: which tracts are affected in SACDSC (2)
symmetrical dorsal and corticospinal tracts
[b12/pern]: which tract loss in SACDSC presents first
dorsal - joint position/vibration sense (ataxia)
[b12/pern]: if SACDSC is left untreated another tract may finally be affected. How does it present.
[b12/pern]: what is the classical triad for SACDSC
Lost reflexes at :
[b12/pern]: which tracts in SACDSC often remain intact regardless of severity
[b12/pern]: what is the pathophysiology behind pernicious anaemia (3 points)
Atrophic gastritis (autoimmune)
Loss of IF
[b12/pern]: which blood group is associated with pernicious anaemia
[b12/pern]: Why in pernicious anaemia should you have a low threshold for gastroscopy i.e. what is it associated with?
carcinoma of stomach
[b12/pern]: What type of anaemia does it causes
[b12/pern]: what would be seen on blood films
[b12/pern]: would you see raised reticulocytosis
NO - production is stopped
it will be reduced or normal
[b12/pern]: Name 2 specific tests for pernicious anaemia
pareital cell antibodies (found in 90%, also 10% without)
Intrinsic factor antibodies (specific but lower sens)
[b12/pern]: below what age would pernicious anaemia be uncommon
[b12/pern]: Tx: 1st line?
Hydroxycobalamin 1mg IM
(alternate days for 2 weeks)
1mg IM every 3 months for life
[b12/pern]: Tx: how frequently and for how long should you inject B12
alternate days every 2 week s
[b12/pern]: Tx: what is maintenance for B12 deficiency
1mg IM hydroxycobalamin every 3 months
[b12/pern]: Tx: how can you check that improvement from treatment has occured?
reticulocytosis after 5 days (therefore increased MCV)
[b12/pern]: B12 deficiency/poor diet and falls at night might suggest what?