[b12/pernicious] Flashcards
(28 cards)
1
Q
A
meat
fish
dairy
2
Q
A
4 years
3
Q
A
intrinsic factor
4
Q
A
thymidine
5
Q
A
pernicious anaemia
gastrectomy
low IF
6
Q
A
ileal resection Crohns coeliacs bacterial overgrowth tapeworm
7
Q
A
angular stomatitis
glossitis (beefy-red sore tongue)
8
Q
A
peripheral neuropathy
9
Q
A
B12 deficiency
10
Q
A
symmetrical dorsal and corticospinal tracts
11
Q
A
dorsal - joint position/vibration sense (ataxia)
12
Q
A
weakness
13
Q
A
extensor plantars
Lost reflexes at :
ankle
knee
14
Q
A
Spinothalamic (P+T)
15
Q
A
Atrophic gastritis (autoimmune)
Loss of IF
achlorhydria
16
Q
A
A
17
Q
A
carcinoma of stomach
18
Q
A
macrocytic
19
Q
A
hypersegmented polymorphs
20
Q
A
NO - production is stopped
it will be reduced or normal
21
Q
A
pareital cell antibodies (found in 90%, also 10% without)
Intrinsic factor antibodies (specific but lower sens)
22
Q
A
<40
23
Q
A
Hydroxycobalamin 1mg IM
(alternate days for 2 weeks)
1mg IM every 3 months for life
24
Q
A
alternate days every 2 week s
25
[b12/pern]: Tx: what is maintenance for B12 deficiency
1mg IM hydroxycobalamin every 3 months
26
[b12/pern]: Tx: how can you check that improvement from treatment has occured?
reticulocytosis after 5 days (therefore increased MCV)
27
[b12/pern]: B12 deficiency/poor diet and falls at night might suggest what?
SACDSC
28
[b12/pern]: Tx: if the cause is dietary what can you revert to after the initial 2 weeks on IM injections
oral b12
