[haemolyticanaemia] Flashcards
(40 cards)
1
Q
A
unconjuated
2
Q
A
normocytic
macrocytic
3
Q
A
urinary urobilinogen
4
Q
A
released during the breakdown of RBCs
5
Q
A
large immature RBC production (reticulocytes)
6
Q
A
T
7
Q
A
intravascular
8
Q
A
haem released in to serum binding with albumin. indicates increased serum haem
9
Q
A
lowered
10
Q
A
binds to free haem and removed by liver
11
Q
A
haemosiderin in the urine
12
Q
A
haptoglobin binding capacity is exceeded
13
Q
A
autoimmune
14
Q
A
antibodies on RBCs
15
Q
A
pre-natal
before blood transfusion
16
Q
A
Warm AIHA
Cold AIHA
paroxysmal cold haemoglobinuria
Drug induced
17
Q
A
drugs bind to RBC cell membrane
18
Q
A
primarily extra-vascular
19
Q
A
the optimum temperature at which the antibodies bind to the RBCs
20
Q
A
IgG
21
Q
A
IgM
22
Q
A
Cold
23
Q
A
viruses
syphilis
24
Q
A
Donath Landsteiner antibodies
25
[haemolytic]: causes: name 3 causes of MAHA
TTP
HUS
DIC
26
[haemolytic]: causes: paroxysmal nocturnal haemoglobinuria is characterised by (2)
haemolysis especially at night
| thrombophila
27
[haemolytic]: causes: hereditary: what mode of inheritance is G-6-PD?
X linked recessive
28
[haemolytic]: causes: hereditary: G6PD deficiency: what precipitates an oxidative crisis?
reduced glutathione production
29
[haemolytic]: causes: hereditary: G6PD deficiency: what is glutathione
an antioxidant
30
[haemolytic]: causes: hereditary: G6PD deficiency: what can precipitate a reduction anti-oxidant production (3)
drugs
Broad beans/fava beans
ilness
31
[haemolytic]: causes: hereditary: G6PD deficiency: what 2 cells are characteristic of this enzyme deficiency?
bite cells
| blister cells
32
[haemolytic]: causes: hereditary: G6PD deficiency: what are heinz bodies
denatured Hb components in RBCs
33
[haemolytic]: causes: hereditary: G6PD deficiency: why do the RBCs in the film look like they have had a bite taken out of the
heinz body removed by the spleen.
34
[haemolytic]: causes: hereditary: G6PD deficiency: what may precipitate an attack
henna
35
[haemolytic]: causes: hereditary: why does pyruvate kinase deficiency causes haemolytic anaemia
decreased ATP production
| reduced RBC lifespan
36
[haemolytic]: causes: hereditary: name 2 membrance defect haemolytics
spherocytosis
| eliptocytosis
37
[haemolytic]: causes: hereditary: why is spherocytosis extra-vascular
RBCs are less deformable
| trapped in spleen
38
[haemolytic]: causes: hereditary: haemoglobinopathies include (2)
sickle cell
| thalassaemia
39
[haemolytic]: causes: hereditary: what causes the heinz bodies to form in G6PD deficiency
oxidative crisis leading to denatured Hb
40
[haemolytic]: what does the indirect coobs test identify
antibodies in serum against RBCS
