Alteplase Recombinant (WK8)

Question 1

Class?

Answer 1

Fibrinolytic

Question 2

Indications?

Answer 2

Fibrinolysis in AMI, acute ischemic shock and pulmonary embolism

Question 3

Contraindications?

Answer 3

Internal bleeding, aortic emergencies, increased ICP, hemorrhagic CVA within 6 months & hypertension

Question 4

Side Effects?

Answer 4

Internal bleeding, superficial bleeding & hemorrhagic CVA

Question 5

Action?

Answer 5

Forms active proteolytic enzyme plasmin, plasmin then degrades fibrin, fibrinogen & clot

Question 6

ADULT?

Answer 6

15 mg then 0.75 mg/kg over 30 min, MAX= 50 mg
Then provide 0.5 mg/kg over 60 min, MAX=35 mg

Question 7

PEDI?

Answer 7

100 mg infusion over 2 hours