Alzheimer's Drugs Flashcards by Sarah Moore

Q

Tacrine (Cognex) Class

A

AChE Inhibitor

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Q

Tacrine (Cognex) MOA

A

Inhibits AChE and BuChE

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Q

Tacrine (Cognex) Therapeutics

A

Mild to moderate Alzheimers

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Q

Tacrine (Cognex) SE

A

Transaminase elevation

2. Nausea, vomiting, diarrhea, abdominal cramping

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Q

Tacrine (Cognex) Misc

A

Metabolized by P450; dosed 4/day; now obsolete

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Q

Donepezil (Aricept) Class

A

AChE inhibitor

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Q

Donepezil (Aricept) MOA

A

Inhibits AChE

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Q

Donepezil (Aricept) Therapeutics

A

Mild to moderate Alzheimers; severe Alzheimers

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Q

Donepezil (Aricept) SE

A

Nausea, vomiting, sleep disturbance

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Q

Donepezil (Aricept) Misc

A

Metabolized by P450; dosed 1/day

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Q

Rivastigmine (Exelon) Class

A

AChE inhibitor

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Q

Rivastigmine (Exelon) MOA

A

Inhibits AChE and BuChE

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Q

Rivastigmine (Exelon) Therapeutics

A

Mild to moderate Alzheimers

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Q

Rivastigmine (Exelon) SE

A

Nausea, vomiting, sleep disturbance

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Q

Rivastigmine (Exelon) Misc

A

Hydrolyzed by cholinesterases; dosed 2/day

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Q

Galantamine (Razadyne) Class

A

AChE inhibitor

Q

Galantamine (Razadyne) MOA

A

Inhibits AChE; allosteric modulator of nicotinic receptors

Q

Galantamine (Razadyne) Therapeutics

A

Mild to moderate Alzheimers

Q

Galantamine (Razadyne) SE

A

Nausea, vomiting, sleep disturbance

Q

Galantamine (Razadyne) Misc

A

Metabolized by P450; dosed 2/day (1/day for ER strength)

Q

Memantine (Namenda) MOA

A

Partial antagonist of NMDA receptor

Q

Memantine (Namenda) Therapeutics

A

Severe Alzheimer’s

Q

Memantine (Namenda) SE

A

Dizziness, confusion, headache, constipation

Q

Memantine (Namenda) Misc

A

Excreted unchanged in urine; dosed 2/day