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Pharm Unit 3 Drugs > Antidepressants > Flashcards

Antidepressants Flashcards

1
Q

Phenelzine (Nardil) Class

A

MAOI

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2
Q

Phenelzine (Nardil) MOA

A

Irreversibly inhibit both MAOa and MAOb, Prevent breakdown of DA

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3
Q

Phenelzine (Nardil) Therpeutics

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

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4
Q

Phenelzine (Naardil) SE

A
  1. Hypertensive crisis (with tyramine-rich foods); serotonin syndrome (MAOI + SSRI); agitation (rare), delerium –> seizures
  2. Anticholinergic, orthostatic hypotension, sexual dysfunction, weight gain, sedation
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5
Q

Desipramine (Norpramin) CLass

A

TCA

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6
Q

Desipramine (Norpramin) MOA

A

Block reuptake of NE or 5-HT at varying potencies and selectivity; also variably block muscarinic, a-adrenergic, dopamine, and histamine receptors

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7
Q

Desipramine (Norpramin) Therapeutics

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

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8
Q

Desipramine (Norpramine) SE

A
  1. Sympathomimetic (cardiac arrhythmias and conduction defects, especially at OD)
  2. Antimuscarinic, orthostatic hypotension, sedation (additive with alcohol), seizures
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9
Q

Desipramine (Norpramine) MIsc

A

Not very safe; rarely used anymore

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10
Q

Imipramine (Tofranil) Class

A

TCA

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11
Q

Imipramine (Tofranil) MOA

A

Block reuptake of NE or 5-HT at varying potencies and selectivity; also variably block muscarinic, a-adrenergic, dopamine, and histamine receptors

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12
Q

Imipramine (Tofranil) Therapeutics

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

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13
Q

Imipramine (Tofranil) SE

A
  1. Sympathomimetic (cardiac arrhythmias and conduction defects, especially at OD)
  2. Antimuscarinic, orthostatic hypotension, sedation (additive with alcohol), seizures
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14
Q

Imipramine (Tofranil) Misc

A

Not very safe; rarely used anymore; forms active metabolite (desipramine)

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15
Q

Amitriptyline (Elavil) Class

A

TCA

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16
Q

Amitriptyline (Elavil) MOA

A

Block reuptake of NE or 5-HT at varying potencies and selectivity; also variably block muscarinic, a-adrenergic, dopamine, and histamine receptors

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17
Q

Amitriptyline (Elavil) Therapeutics

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism; prevention of tension headaches, migraines

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18
Q

Amytriptyline (elavil) SE

A
  1. Sympathomimetic (cardiac arrhythmias and conduction defects, especially at OD)
  2. Antimuscarinic, orthostatic hypotension, sedation (additive with alcohol), seizures
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19
Q

Amytriptyline (Elavil) Misc

A

Not very safe; rarely used anymore; forms active metabolite (nortriptyline)

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20
Q

Nortriptyline (Pamelor) Class

A

TCA

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21
Q

Nortriptyline (Pamelor) MOA

A

Block reuptake of NE or 5-HT at varying potencies and selectivity; also variably block muscarinic, a-adrenergic, dopamine, and histamine receptors

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22
Q

Nortriptyline (Pamelor) Therapeutics

A

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

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23
Q

Nortriptyline (Pamleor) SE

A
  1. Sympathomimetic (cardiac arrhythmias and conduction defects, especially at OD)
  2. Antimuscarinic, orthostatic hypotension, sedation (additive with alcohol), seizures
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24
Q

Nortriptyline (Pamelor) Misc

A

Not very safe; rarely used anymore

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25
Fluoxetine (Prozac) Class
SSRI
26
Fluoxetine (Prozac) MOA
Inhibit reuptake of 5-HT (and NE to lesser extent)
27
Fluoxetine (Prozac) Therpeutics
Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism; pre-menstrual dystrophic disorder
28
Fluoxetine (Prozac) SE
1. Serotonin syndrome (with MAOIs) | 2. Fewer than tricyclics; mostly nausea, decreased sexual function
29
Fluoxetine (Prozac) Misc
Potent P450 inhibitor; forms active metabolite (norfluoxetine)
30
Paroxetine (Paxil) Class
SSRI
31
Paroxetine (Paxil) MOA
Inhibit reuptake of 5-HT (and NE to lesser extent)
32
Paroxetine (Paxil) Therapeutics
Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
33
Paroxetine (Paxil) SE
1. Serotonin syndrome (with MAOIs) | 2. Fewer than tricyclics; mostly nausea, decreased sexual function
34
Paroxetine (Paxil) Misc
Potent P450 inhibitor
35
Sertraline (Zoloft) Class
SSRI
36
Sertraline (Zoloft) MOA
Inhibit reuptake of 5-HT (and NE to lesser extent)
37
Sertraline (Zoloft) Therapeutics
Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
38
Sertraline (Zoloft) SE
1. Serotonin syndrome (with MAOIs) | 2. Fewer than tricyclics; mostly nausea, decreased sexual function
39
Escitalopram (Lexapro) Class
SSRI
40
Escitalopram (Lexapro) MOA
Inhibit reuptake of 5-HT (and NE to lesser extent)
41
Escitalopram (Lexapro) Therapeutics
Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
42
Escitalopram (Lexapro) SE
1. Serotonin syndrome (with MAOIs) | 2. Fewer than tricyclics; mostly nausea, decreased sexual function
43
Citalopram (Celexa) Class
SSRI
44
Citalopram (Celexa) MOA
Inhibit reuptake of 5-HT (and NE to lesser extent)
45
Citalopram (Celexa) Therapeutics
Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
46
Citalopram (Celexa) SE
1. Serotonin syndrome (with MAOIs) | 2. Fewer than tricyclics; mostly nausea, decreased sexual function
47
Duloxetine (Cymbalta) Class
SNRI
48
Duloxetine (Cymbalta) MOA
Inhibits reuptake of 5-HT and NE
49
Duloxetine (Cymbalta) Therapeutics
Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
50
Venlafaxine (Effexor) CLass
SNRI
51
Venlafaxine (Effexor) MOA
Inhibits reuptake of 5-HT and NE
52
Venlafaxine (Effexor) Therapeutics
Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
53
Bupropion (Wellbutrin) Class
Atypical
54
Bupropion (Wellbutrin) MOA
Blocks DA and NE reuptake
55
Bupropion (Wellbutrin) Therapeutics
Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism; maintain nicotine abstinence in quitting smokers
56
Bupropion (Wellbutrin) SE
Lowers seizure threshold
57
Mirtazapine (Remeron) Class
Atypical
58
Mirtazapine (Remeron) MOA
5HT2a antagonists; also inhibit 5HT reuptake
59
Mirtazapine (Remeron) THerapeutics
Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism
60
Lithium MOA
Unknown; lithium depletes secondary messengers IP3 and DAG, important in a-adrenergic and muscarinic-cholinergic transmission
61
Lithium Therapeutics
Anti-manic/mood-stabilizing (bipolar); long-term cluster headache prevention
62
Lithium SE
1. If elevated levels: neurotoxicity, cardiac toxicity, renal dysfunction 2. Drowsiness, weight gain, tremor, polydipsia, polyuria
63
Lithium Misc
Nausea and vomiting early sign of lithium OD; indomethacin and Na-depleting diuretics should be avoided (increase [Li])

Pharm Unit 3 Drugs (13 decks)

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