Non-Medical Drugs

Question 1

Nalmefene (Revex) Class

Answer 1

Opioid antagonist

Question 2

N-acetylcysteine (Mucomyst) Class

Answer 2

Antioxidant

Question 3

Cocaine Class

Answer 3

CNS stimulant

Question 4

LSD Class

Answer 4

Schedule I Hallucinogen

Question 5

Mescaline Class

Answer 5

Schedule I Hallucinogen

Question 6

Psilocybin Class

Answer 6

Schedule I Hallucinogen

Question 7

Phencyclidine (PCP) Class

Answer 7

Dissociative anesthetic

Question 8

Marijuana (THC) Class

Answer 8

Cannabinoid

Question 9

Anandamide Class

Answer 9

Endogenous cannabinoid

Question 10

Dronabinol (Marinol) Class

Answer 10

Synthetic THC

Question 11

Nabilone (Cesamet) Class

Answer 11

Synthetic THC

Question 12

N-acetylcysteine (Mucomyst) MOA

Answer 12

Supplies sulfhydryl groups to glutathione; improves microcirculation, provides anti-inflammatory effect

Question 13

Fomepizole (Antizol) MOA

Answer 13

Blocks alcohol dehydrogenase

Question 14

Cocaine MOA

Answer 14

Blocks reuptake of dopamine, norepinephrine, and serotonin

Question 15

LSD MOA

Answer 15

Agonist at 5HT2A receptors on Raphe cell body –> inhibition of Raphe Nuclei firing –> increased sensory input; partial dopamine agonist

Question 16

Mescaline MOA

Answer 16

Agonist at 5HT2A receptors on Raphe cell body –> inhibition of Raphe Nuclei firing –> increased sensory input; partial dopamine agonist

Question 17

Psilocybin MOA

Answer 17

Agonist at 5HT2A receptors on Raphe cell body –> inhibition of Raphe Nuclei firing –> increased sensory input; partial dopamine agonist

Question 18

Phencyclidine (PCP) MOA

Answer 18

Antagonist of ion channel associated with NDMA receptor; agonist at mu opioid receptors

Question 19

Amphetamines (Benzadrine) MOA

Answer 19

Indirect sympathomimetic (release biologic amines from nerve terminals in periphery and in CNS); dopamine most important

Question 20

Marijuana (THC) MOA

Answer 20

Hits cannabinoid receptors (CB1, CB2: G-protein coupled receptors)

Question 21

Anandamide MOA

Answer 21

Hits cannabinoid receptors (CB1, CB2: G-protein coupled receptors)

Question 22

Dronabinol (Marinol) MOA

Answer 22

Hits cannabinoid receptors (CB1, CB2: G-protein coupled receptors)

Question 23

Nabilone (Cesamet) MOA

Answer 23

Hits cannabinoid receptors (CB1, CB2: G-protein coupled receptors)

Question 24

N-acetylcysteine (Mucomyst) Theurapeutics

Answer 24

Acetaminophen overdose

Question 25

Fomepizole (Antizol) Theurapeutics

Answer 25

Methanol & ethylene glycol poisoning

Question 26

Cocaine Theurapeutics

Answer 26

Topical anesthetic, combined vasoconstrictor and local anesthetic

Question 27

LSD Theurapeutics

Answer 27

Schedule I hallucinogen; model hallucinogen against which all others compared; limited studies in psychoanalysis, alcoholism, autistic children, and terminal cancer patients

Question 28

Amphetamines (Benzadrine) Theurapeutics

Answer 28

Narcolepsy, ADHD

Question 29

Marijuana (THC) Theurapeutics

Answer 29

Schedule I hallucinogen; anti-emetic, anti-nausea, and appetite stimulate for cancer chemotherapy and AIDS patients; analgesic for neuropathic pain; potentially: glaucoma, asthma, anxiolytic, migraine, and multiple sclerosis treatment

Question 30

Anandamide Theurapeutics

Answer 30

Endogenous cannabinoid

Question 31

Dronabinol (Marinol) Theurapeutics

Answer 31

Schedule III drug; anti-emetic, anti-nausea, and appetite stimulate for cancer chemotherapy and AIDS patients

Question 32

Nabilone (Cesamet) Theurapeutics

Answer 32

Schedule II drug; treatment-resistant nausea and vomiting, weight loss and anorexia in AIDS patients

Question 33

Nalmefene (Revex) SE

Answer 33

May produce a prolonged withdrawal state (nausea, vomiting, piloerection, yawning)

Question 34

Cocaine SE

Answer 34

Sympathetic effects; paranoia, aggression

Question 35

LSD SE

Answer 35

Bad trips (anxiety attack, panic attack), flashbacks, "street drug" lifestyle; no overdoses, birth defects, or chronic psychoses linked to LSD

Question 36

Phencyclidine (PCP) SE

Answer 36

1. Violent behavior, coma, seizures, arrest; inexplicable psychoses 2. Dissociation, confusion, ataxia, marked nystagmus

Question 37

Amphetamines (Benzadrine) SE

Answer 37

1. Vasospasm leading to possible stroke or MI, arrhythmia, weight loss (anorectic effect) 2. Tremor, anxiety, irritability, confusion, possibly paranoid state

Question 38

Marijuana (THC)

Answer 38

1. Vasodilation --> tachycardia, dilation of conjunctival vessels, bronchodilation, decreased intraocular pressure, hunger 2. May impair reproductive function in adolescents; heavy use may impair development of very young users; possible respiratory damage due to tar

Question 39

Fomepizole (Antizol) Misc

Answer 39

Very expensive

Question 40

Cocaine Misc

Answer 40

Rapidly hydrolyzed by plasma cholinesterase; crack is the free base form

Question 41

LSD Misc

Answer 41

Oxidized in liver; cross tolerance with mescaline and psilocybin

Question 42

Mescaline Misc

Answer 42

Cross tolerance with LSD and psilocybin

Question 43

Psilocybin Misc

Answer 43

Cross tolerance with mescaline and LSD

Question 44

Phencyclidine (PCP) Misc

Answer 44

Long half-life due to being highly lipid soluble and having active metabolites

Question 45

Amphetamines (Benzadrine) Misc

Answer 45

Others: dextroamphetamine (Dexedrine), methamphetamine (Desoxyn), methylphenidate (Ritalin)

Question 46

Marijuana (THC) Misc

Answer 46

Active ingredient is delta-9-tetrahydrocannabinol; metabolized by P450, with chronic use inducing enzyme; highly lipid soluble

Question 47

Nabilone (Cesamet) Misc

Answer 47

Less psychoactive side effects than marijuana

Question 48

Nalmefene (Revex) Class

Answer 48

Opiod antagonist