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Pharm Unit 3 Drugs > Narcotics > Flashcards

Narcotics Flashcards

1
Q

Other SE for all opioids

A

Dry mouth, nausea/vomiting, sedation, sweating; dreams, dysphoria, delerium, myoclonus, seizures, pruritis, urticaria, urinary incontinence

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2
Q

Morphine Class

A

Opioid

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3
Q

Codeine Class

A

Opioid

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4
Q

Tramadol (Ultram) Class

A

Opioid

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5
Q

Fentanyl (Duragesic) Class

A

Opioid

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6
Q

Methadone (Methadose) Class

A

Opioid

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7
Q

Oxycodone Class

A

Opioid

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8
Q

Meperidine (Demerol) Class

A

Opioid

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9
Q

Loperamide (Imodium) Class

A

Opioid

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10
Q

Diphenoxylate (Lomotil) Class

A

Opioid

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11
Q

Naloxone (Narcan) Class

A

Opioid antagonist

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12
Q

Naltrexone (Revia) Class

A

Opioid antagonist

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13
Q

Morphine MOA

A

Mu-opioid receptor agonist

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14
Q

Codeine MOA

A

Mu-opioid receptor agonist (low receptor affinity); demethylated to form morphine (10% of oral ingestion, via CYP2D6)

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15
Q

Tramadol (Ultram) MOA

A

Mu opioid receptor agonist (weak); some NE/5HT uptake inhibition (leading to analgesia); synthetic codeine analog

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16
Q

Fentanyl (Duragesic)MOA

A

Mu-opioid receptor agonist (strong); highly lipid-soluble

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17
Q

Methadone (Methadose) MOA

A

Mu-opioid receptor agonist

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18
Q

Oxycodone MOA

A

Mu-opioid receptor agonist

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19
Q

Meperidine (Demerol) MOA

A

Mu-opioid receptor agonist

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20
Q

Loperamide (Imodium) MOA

A

Slows peristalsis via opioid receptors in intestine, and possibly decreased GI secretion

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21
Q

Diphenoxylate (Lomotil) MOA

A

Slows peristalsis via opioid receptors in intestine, and possibly decreased GI secretion

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22
Q

Naloxone (Narcan) MOA

A

Competitive mu-, delta-, and kappa-opioid receptor antagonist

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23
Q

Naltrexone (Revia)MOA

A

Mu-opioid receptor antagonist

24
Q

Morphine Therapeutics

A

Severe analgesia, mood alteration, antitussive, sedation

25
Codeine Therapeutics
Moderate analgesia, antitussive (found in many cough medicines)
26
Tramadol (Ultram)Therapeutics
Moderate (not severe) analgesia
27
Fentanyl (Duragesic) Therapeutics
Severe analgesia after identification of dose level via other opiod (e.g., morphine)
28
Methadone (Methadose) Therapeutics
Chronic, severe pain; treatment of heroin and opiod addicts
29
Oxycodone Therapeutics
Moderate to severe analgesia
30
Meperidine (Demerol) Therapeutics
Don't use this
31
Loperamide (Imodium) Therapeutics
Diarrhea
32
Diphenoxylate (Lomotil) Therapeutics
Diarrhea
33
Naloxone (Narcan) Therapeutics
Acute opioid toxicity (depressed RR best predicts reponse)
34
Naltrexone (Revia) Therapeutics
Alcoholism
35
Morphine SE
Miosis, constipation, respiratory depression
36
Codeine SE
Miosis, constipation, respiratory depression
37
Tramadol (Ultram) SE
Miosis, constipation, respiratory depression
38
Fentanyl (Duragesic) SE
Miosis, constipation, respiratory depression
39
Methadone (Methadose) SE
Miosis, constipation, respiratory depression
40
Oxycodone SE
Miosis, constipation, respiratory depression
41
Meperidine (Demerol) SE
Miosis, constipation, respiratory depression; mental status changes and seizures (normeperidine)
42
Loperamide (Imodium) SE
Miosis, constipation, respiratory depression
43
Diphenoxylate (Lomotil) SE
Miosis, constipation, respiratory depression
44
Naloxone (Narcan) SE
Can precipitate withdrawal (flu-like symptoms of nausea, vomiting, diarrhea; piloerection, yawning, irritability)
45
Naltrexone (Revia) SE
May produce a prolonged withdrawal state (nausea, vomiting, piloerection, yawning)
46
Morphine Misc
2 major active metabolites: M6 (more potent/active), M3 (little affinity); intraspinal administration possible
47
Codeine Misc
10% of Caucasians unable to convert codeine to morphine (can still experience side effects, though)
48
Tramadol (Ultram) Misc
1 metabolite: demethylated, more potent analgesic
49
Fentanyl (Duragesic) Misc
IV, transdermal; do not change dose more than 1/week (long half-life); intraspinal administration possible
50
Methadone (Methadose) Misc
90% bound to plasma protein, accumulates in tissues (thus, extended duration of action); do not change dose more than 1/week (long half-life)
51
Oxycodone Misc
Oxycontin is extended release
52
Meperidine (Demerol) Misc
1 metabolite: normeperidine
53
Loperamide (Imodium) Misc
Meperidine congener
54
Diphenoxylate (Lomotil) Misc
Meperidine congener
55
Naloxone (Narcan) Misc
Continuous parenteral infusion, as lasts only 15-30 minutes (oral almost completely metabolized by liver); patient has normal mental status

Pharm Unit 3 Drugs (13 decks)

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