Amino acid derivates (and something about B12 defic)

Question 1

B12 deficiency leads to build up of what 2 things?

Answer 1

homocysteine (cysteine= end product)
methylmalonyl acid (succinyl co A = end product)

Question 2

amino acid derivative of DA, NE, Epi?

Answer 2

Phe –> Tyr (req BH4)

DA (dopadecarboxylase)(req B6) –> NE (dopamine betacarboxylase)(req Vit C) –> Epi (PNMT)(req SAM)

Question 3

amino acid derivative of 5HT? what else does it synth?

Answer 3

Tryp

5HT (BH4, B6) –> melatonin
Niacin (B2, B6)

Question 4

amino acid derivative of histamine?

Answer 4

histadine (req B6)

Question 5

amino acid derivative of heme?

Answer 5

glycine –> B6 –> pophyrin

Question 6

amino acid deriv of GABA and glutathione?

Answer 6

glutamate (req B6)

Question 7

arginine gives rise to?

Answer 7

creatine, urea, nitric oxide (req BH4)

Question 8

where does melanin come from?

Answer 8

Dopa, on its way to DA

tyr – (BH4) –> dopa –> DA

Question 9

B12 deficiency in the spinal cord?

Answer 9

Subacute combined degeneration (SCD)

• Spinocerebellar tracts
• Coritcospinal tracts (lateral)
• Dorsal columns

-ataxic gait, impaired position/ vibration, paresthesia

Question 10

B6 is a cofactor for what important substances in general?

Answer 10

NEUROTRANSMITTERS!!!!!!!!!!!