hypersensitivity reactions Flashcards
1
Q
type I (immediate)
A
IgE
- basophils + mast cells
- ANAPHYLAXIS, ALLERGIES
2
Q
type II (cytotoxic)
A
IgM, IgG autoantibodies
- complement activation
- nk, Eos, nuets, macs
- AUTOIMMUNE HEMOLYTIC ANEMIA
- hemolytic dz of newborn (Rh)
- GOODPASTURES
3
Q
what is a transfusion reaction?
A
- acute hemolytic anemia, type II hypersensitivity
- minutes to hours
- hemoglobinuria, fevers, chills, chest/back pain
4
Q
type III (immune complex)
A
- ag-ab, complement
- neutrophils
- serum sickness, PSGN, lupus nephritis
**anything with “membrano” in kideny
5
Q
type IV (delayed)
A
- T cells, Macs –> NO humoral component
- contact dermatitis
- tuberculin skin test
6
Q
timeframe of serum sickness? What type of reaction? What will blood show on labs? What will histology show?
A
7-14 days
III
decreased C3
firbinoid necrosis, intense neutrophil inflammation
7
Q
tryptase
A
released from mast cells in anaphylaxis
