cell injury Flashcards
coag necrosis
ischemic infarcts (except brain)
preserved cell shape/ organ structure but nucleus dissapears
liquefactive necrosis. 3 examples.
proteloytic lysis of tissue
brain - microglia
abcess
pancreas- parenchyma
what types of necrosis are seen in pancreatitis?
liquefactive of parenchyma by autodigestion
fat necrosis of peri-parenchymal fat
caseous necrosis
“liquefactive with stuff added in (bacteria)” (liquefactive + coag)
granulomatous inflammation due to TB or fungi
fat necrosis. 2 places you see it.
chalky white, calcium deposition
trauma to fat- breast
pancreatitis
saponification
fatty acids released by trauma or lipase join with Ca
dystrophic calcification. What are examples? associated lab values?
Ca deposits in dead tissue
ex= saponification, psammomma bodies
NORMAL Ca, PO4
metastatic calcification is differentiated from dystrophic calcification by?
HIGH serum ca and po4
fibrinoid necrosis
damage to blood vessel wall
bright pink stain (protein leakage into vessel wall)
malignant HTN, vasculitis, pre-eclampsia (placenta)
CCL4
swelling of RER –> impair protein synth
repurfision injury
O2 free radicals, continued rise in cardiac enzymes
function of BCL2
prevents release of cyt-c from mitomembrane thus preventing activation of caspases
hypoxia effect at tissue
low ATP, disrupts na/k pump
high sodium and water in cell
high calcium in cell
lactic acid build up
hallmark of REVERSIBLE injury
cell swelling
hallmark of IRREVERSIBLE injury
membrane damage
mito- loss of cyt-c —> apoptosis
lyosome –> leaks hydrolytic enzymes, activated by increased IC Ca
plasma membrane –> leak enzymes, build up IC Ca
