inherited hyperlipoproteinemias

Question 1

familial chylomicronemia (I)

Answer 1

defect= LPL, ApoCII
increase= chylomicrons

sx= ACUTE PANC, lipemia retinalix, xanthomas, HSM

Question 2

familial hypercholesterolemia (IIA)

Answer 2

defect= LDL-r, ApoB-100
increase= LDL

sx= CAD, tendon xanthoma, xanthelasmas

Question 3

Familial dysbetalipoproteinemia (III)

Answer 3

defect= ApoE
increase= chylo and VLDL

sx= CAD/PAD

Question 4

familiarly hypertriglyceridemia (IV)

Answer 4

dfect= ApoA-V
increase= VLDL
sx= panc