transplant rejection Flashcards
1
Q
ONSET TIME (hyper acute, acute, chronic)
A
hyperacute= minutes to hours (type II)
acute= <6months (IV)
chronic= months to years (II/IV)
2
Q
etiology of hyperacute
A
PREFORMED AB against graft ABO ag IN HOST
type II
3
Q
morphology of hyperacute
A
- gross mottling, cyanosis
- arterial fibrinoid necrosis, capillary thrombotic occlusion
4
Q
etiology of acute
A
donor ag create HUMORAL/CELLULAR ACTIVATION OF NAIVE IMMUNE CELLS
5
Q
morphology of acute
A
humoral: C4D dep, neus, necrotizing vasculitis
cellular: lymph interstitial infiltrate
6
Q
pharm to prevent acute rejection?
A
immunosuppressants
7
Q
chronic –> exampls
A
bronchiolitis obliterans
accelerated atheroscloerosis
chronic graft nephropatyh
vanishing bile duct syndrome
8
Q
GVHD
A
GRAFT immune T cells proliferate in immunocompromised host, reject host cells
- severe organ dysfx
- maculopapular rash, jaundice, diarrhea, HSM
- liver and BM transplant
