Amlodipine Flashcards
1
Q
What class of drug is amlodipine?
A
Dihydropyridine CCB
2
Q
What are the uses of amlodipine?
A
Hypertension
Stable angina
3
Q
What is the mechanism of action of amlodipine?
A
calcium channel blocker
- selective for peripheral vasculature
- inhibits Ca2+ influx to vascular smooth muscles
- causes vasodilation
- decreases peripheral vascular resistance + cardiac workload
4
Q
What are the adverse effects of amlodipine?
A
- dizziness + headache
- drowsiness
- N+V
- ankle swelling
- flushing
- palpitations
5
Q
What are important drug drug interactions with amlodipine?
A
Amlopidine + simvastatin
Increases effect of statin
6
Q
Contraindications of amlodipine
A
Unstable angina
Severe aortic stenosis
Cardiogenic shock
