celecoxib Flashcards
1
Q
What class of drug is Celecoxib?
A
NSAID
COX-2 selective inhibitor
2
Q
What are the uses of Celecoxib?
A
- pain + inflammation in OA + RA
- ankylosing spondylitis
3
Q
What is the mechanism of action of Celecoxib?
A
selective COX-2 inhibitor
- reduction in prostacyclin (PGI2) synthesis > analgesic affects
- not anti platelet
4
Q
What are adverse drug reactions of Celecoxib?
A
- weight gain
- diarrhoea
- nausea
- reduced GFR
- dysphagia
- MI
5
Q
What are important drug drug interactions of Celecoxib?
A
- aspirin
- anticoagulants
- ACEi + ARBs
- diuretics
