Furosemide Flashcards
1
Q
What class of drug is furosemide?
A
Loop diuretic
2
Q
What are the uses of furosemide?
A
Oedema
Hypertension
Fluid overload in heart failure
Nephrotic syndrome
3
Q
What is the mechanism of action of furosemide?
A
loop diuretic
- acts in the loop of henle
- inhibits the NKCC cotransporter
- reduced Na/K/Cl into epithelium (more in nephron) > H2O follows
.
- direct dilatation of capacitance veins > reduces preload
4
Q
What are the adverse effects of furosemide?
A
- dehydration
- hypokalaemia (alkalosis) + hyponatremia
- hypotension
- gout
- ototoxicity > tinnitus
5
Q
What are important drug drug interactions with furosemide?
A
Aminoglycosides - also otoxic
Digoxin
Lithium
6
Q
What are the contraindications of furosemide?
A
Hypokalaemia + hyponatremia
Gout
Hepatic encephalopathy
