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1

What is anemia

a reduction below normal in hemoglobin or red blood cell number

2

What are the two components of a complete blood count (CBC)

Mean corpuscular volume (MCV)
Mean corpuscular hemoglobin concentration (MCHC)

3

What does the Mean Corpuscular Volume (MCV) measure

the size of the Red blood cell

4

What are the terms for a low, normal, and high MCV

low MCV = microcytic
normal MCV = Normocytic
high MCV = macrocytic

5

what does it mean if a RBC is macrocytic

that the RBC is abnormally large

6

what does it mean if a RBC is normocytic

that the RBC is the normal size

7

what does it mean if a RBC is microcytic

that the RBC is abnormally small

8

What does the Mean Corpuscular hemoglobin concentration (MCHC) measure

it measures the amount of hemoglobin in the RBC

9

What are the terms for low, normal, and high MCHC

low MCHC = hypochromic
normal MCHC = normochromic
high MCHC = DOESN'T HAPPEN

10

What does it mean if a RBC is hypochromic

that the RBC has an abnormally low hemoglobin concentration

11

what does it mean if a RBC is normochromic

that the RBC has a normal hemoglobin concentration

12

What are the three different types of abnormalities that a RBC can have

1. Size varation
2. Hemoglobin concentration
3. Shape variation

13

what is the term for variation in RBC shape

poikilocytosis

14

What are the symptoms of anemia

1. pale skin/mucus membranes
2. jaundice (if hemolytic)
3. breathlessness
4. tachycardia
5. dizziness
6. fatigue

15

What symptom of anemia is specific to hemolytic anemia

Jaundice

16

What are the three main causes of anemia

1. Blood loss
2. Excessive RBC destruction
3. Insufficient RBC production

17

What are the two types of reasons for excessive RBC destruction

1. extracorpuscular reasons
2. intracorpuscular reasons

18

What are the three reasons for insufficient RBC production

1. too little material
2. too few erythroblasts
3. not enough room

19

What is the specific cause of anemia caused by blood loss

trauma resulting in acute blood loss

20

anemia caused by acute blood loss due to trauma will result in an increase of what

reticulocytes

21

what are reticulocytes

immature RBCs

22

how long does it take a reticulocyte to develop into a mature RBC after it has left the bone marrow and entered the blood

about one day

23

What is the normal percentage of RBCs in the blood that are reticulocytes

1%

24

What are the two types of signs that we will see when a patient is suffering from anemia due to excessive destruction of RBCs

signs of the excessive destruction
signs of an increase in production of RBCs (due to anemia)

25

What are the three signs of destruction of RBC

1. increased bilirubin
2. increased LDH
3. reduced haptoglobin

26

What are the two signs of increased production of RBCs

1. increased reticulocytes
2. nucleated red cells in blood

27

what is the life span of RBCs

120 days

28

Where are RBC destroyed

the liver and the spleen (NOT KIDNEYS)

29

What are RBCs broken down into in the spleen and liver

1. Globin
2. Heme

30

after RBCs are broken down in the spleen and liver what is the globin used for

the globin is used in Amino Acid formation